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	Provedor de dados BJMBR (1) Genet. Mol. Biol. (1) Autor Baruffi,Marcelo Razera (1) Engel,Edgard Edward (1) Ferriani,R.A. (1) Martelli,L. (1) Meola,J. (1) Rogatto,Silvia Regina (1) Rosa e Silva,J.C. (1) Santos,S.A. (1) Squire,J.A. (1) Squire,Jeremy Andrew (1) Tone,Luis Gonzaga (1) Veiga-Castelli,L.C. (1) Yoshimoto,M. (1) Mais... Palavra-chave Comparative genomic hybridization (2) CGH (1) Chromosomal imbalances (1) Endometrioma (1) Endometriosis (1) Ewing's Sarcoma (1) Osteosarcoma (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2003 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Chromosomal imbalances detected in primary bone tumors by comparative genomic hybridization and interphase fluorescence in situ hybridization Genet. Mol. Biol. Baruffi,Marcelo Razera; Engel,Edgard Edward; Squire,Jeremy Andrew; Tone,Luis Gonzaga; Rogatto,Silvia Regina. We applied a combination of comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH), to characterize the genetic aberrations in three osteosarcomas (OS) and one Ewing's sarcoma. CGH identified recurrent chromosomal losses at 10p14-pter and gains at 8q22.3-24.1 in OS. Interphase FISH allowed to confirm 8q gain in two cases. A high amplification level of 11q12-qter was detected in one OS. The Ewing's sarcoma showed gain at 1p32-36.1 as the sole chromosome alteration. These studies demonstrate the value of molecular cytogenetic methods in the characterization of recurrent genomic alterations in bone tumor tissue. Tipo: Info:eu-repo/semantics/article Palavras-chave: Comparative genomic hybridization; CGH; Osteosarcoma; Ewing's Sarcoma. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000200001 Genomic alterations detected by comparative genomic hybridization in ovarian endometriomas BJMBR Veiga-Castelli,L.C.; Rosa e Silva,J.C.; Meola,J.; Ferriani,R.A.; Yoshimoto,M.; Santos,S.A.; Squire,J.A.; Martelli,L.. Endometriosis is a complex and multifactorial disease. Chromosomal imbalance screening in endometriotic tissue can be used to detect hot-spot regions in the search for a possible genetic marker for endometriosis. The objective of the present study was to detect chromosomal imbalances by comparative genomic hybridization (CGH) in ectopic tissue samples from ovarian endometriomas and eutopic tissue from the same patients. We evaluated 10 ovarian endometriotic tissues and 10 eutopic endometrial tissues by metaphase CGH. CGH was prepared with normal and test DNA enzymatically digested, ligated to adaptors and amplified by PCR. A second PCR was performed for DNA labeling. Equal amounts of both normal and test-labeled DNA were hybridized in human normal... Tipo: Info:eu-repo/semantics/article Palavras-chave: Endometrioma; Endometriosis; Comparative genomic hybridization; Chromosomal imbalances. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000800014 Registros recuperados: 2 Primeira ... 1 ... Última

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