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	Provedor de dados 80 (1) Autor Batool,Maleeha Waqar and Sidra (1) Palavra-chave Alzheimer’s dieases (1) Antagonists (1) Conantokins (1) Docking (1) Glutamate (1) In silico (1) N-methyl-D-aspartate (1) NR2B (1) Neurotransmitter (1) Synaptic plasticity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última In silico analysis of binding interaction of conantokins with NMDA receptors for potential therapeutic use in Alzheimer’s disease 80 Batool,Maleeha Waqar and Sidra. Abstract Background The N-methyl-D-aspartate (NMDA) receptors are glutamate receptors that play vital roles in central nervous system development and are involved in synaptic plasticity, which is an essential process for learning and memory. The subunit N-methyl D-aspartate receptor subtype 2B (NR2B) is the chief excitatory neurotransmitter receptor in the mammalian brain. Disturbances in the neurotransmission mediated by the NMDA receptor are caused by its overexposure to glutamate neurotransmitter and can be treated by its binding to an antagonist. Among several antagonists, conantokins from cone snails are reported to bind to NMDA receptors. Methods This study was designed to analyze the binding mode of conantokins with NMDA receptors in both humans... Tipo: Info:eu-repo/semantics/article Palavras-chave: N-methyl-D-aspartate; Glutamate; Synaptic plasticity; NR2B; Neurotransmitter; Antagonists; Conantokins; Docking; In silico; Alzheimer’s dieases. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100317 Registros recuperados: 1 Primeira ... 1 ... Última

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