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	Provedor de dados BJMBR (2) Autor Auler Jr.,J.O.C. (1) Bulow,N.M.H. (1) Carmona,M.J.C. (1) Colpo,E. (1) Correa,E.F.M. (1) Duarte,M.F. (1) Malbouisson,L.M.S. (1) Pereira,R.P. (1) Pereira,V.A. (1) Rocha,J.B.T. (1) Santos,S.R.C.J. (1) Waczuk,E.P. (1) Mais... Palavra-chave Coronary artery bypass grafting surgery (2) Atenolol (1) Cardiopulmonary bypass (1) Cytokines (1) Dexmedetomidine (1) Mini-cardiopulmonary bypass (1) Pharmacokinetics (1) Propranolol (1) Systemic inflammatory response syndrome (1) Total intravenous anesthesia (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2016 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effect of cardiopulmonary bypass on the pharmacokinetics of propranolol and atenolol BJMBR Carmona,M.J.C.; Pereira,V.A.; Malbouisson,L.M.S.; Auler Jr.,J.O.C.; Santos,S.R.C.J.. The pharmacokinetics of some β-blockers are altered by cardiopulmonary bypass (CPB). The objective of this study was to compare the effect of coronary artery bypass graft (CABG) surgery employing CPB on the pharmacokinetics of propranolol and atenolol. We studied patients receiving oral propranolol with doses ranging from 80 to 240 mg (N = 11) or atenolol with doses ranging from 25 to 100 mg (N = 8) in the pre- and postoperative period of CABG with moderately hypothermic CPB (32°C). On the day before and on the first day after surgery, blood samples were collected before β-blocker administration and every 2 h thereafter. Plasma levels were determined using high-performance liquid chromatography and data were treated by pharmacokinetics-modelling.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Propranolol; Atenolol; Pharmacokinetics; Coronary artery bypass grafting surgery; Cardiopulmonary bypass. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600016 Dexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypass BJMBR Bulow,N.M.H.; Colpo,E.; Pereira,R.P.; Correa,E.F.M.; Waczuk,E.P.; Duarte,M.F.; Rocha,J.B.T.. Cardiopulmonary bypass (CPB) with extracorporeal circulation produces changes in the immune system accompanied by an increase in proinflammatory cytokines and a decrease in anti-inflammatory cytokines. We hypothesize that dexmedetomidine (DEX) as an anesthetic adjuvant modulates the inflammatory response after coronary artery bypass graft surgery with mini-CPB. In a prospective, randomized, blind study, 12 patients (4 females and 8 males, age range 42-72) were assigned to DEX group and compared with a conventional total intravenous anesthesia (TIVA) group of 11 patients (4 females and 7 males). The endpoints used to assess inflammatory and biochemical responses to mini-CPB were plasma interleukin (IL)-1, IL-6, IL-10, interferon (INF)-γ, tumor necrosis... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytokines; Systemic inflammatory response syndrome; Total intravenous anesthesia; Dexmedetomidine; Coronary artery bypass grafting surgery; Mini-cardiopulmonary bypass. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400702 Registros recuperados: 2 Primeira ... 1 ... Última

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