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	Provedor de dados Anais da ABC (AABC) (1) BJMBR (1) Autor Berlese,D.B. (1) Busso,Cleverson (1) Castro-Prado,Marialba A. A. (1) Mello,C.F. (1) Rubin,M.A. (1) Sauzem,P.D. (1) Tabarelli,Z. (1) Mais... Palavra-chave Cremophor EL (2) Antineoplasm agents (1) Antinociception (1) Aspergillus nidulans (1) Dipyrone (1) Homozygotization Index (1) Mitotic recombination (1) Morphine (1) Tail immersion test (1) Writhing test (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2004 (1) 2003 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans Anais da ABC (AABC) Busso,Cleverson; Castro-Prado,Marialba A. A.. Cremophor EL is a solubilizer and emulsifier agent used in the pharmaceutical and foodstuff industries. The solvent is the principal constituent of paclitaxel's clinical formulation vehicle. Since mitotic recombination plays a crucial role in multistep carcinogenesis, the study of the recombinagenic potential of chemical compounds is of the utmost importance. In our research genotoxicity of cremophor EL has been studied by using an uvsH//uvsH diploid strain of Aspergillus nidulans. Since it spends a great part of its cell cycle in the G2period, this fungus is a special screening system for the study of mitotic recombination induced by chemical substances. Homozygotization Indexes (HI) for paba and bi markers from heterozygous B211//A837 diploid strain were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aspergillus nidulans; Mitotic recombination; Cremophor EL; Homozygotization Index; Antineoplasm agents. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100005 Antinociceptive effects of Cremophor EL orally administered to mice BJMBR Tabarelli,Z.; Berlese,D.B.; Sauzem,P.D.; Mello,C.F.; Rubin,M.A.. Surfactants are frequently used to improve solubilization of lipophilic drugs. Cremophor EL (CrEL) is a polyoxyethylated castor oil surfactant used to solubilize water-insoluble drugs such as anesthetic, antineoplastic, immunosuppressive and analgesic drugs, vitamins and new synthetic compounds, including potential analgesics. The antinociceptive effect of CrEL (3.2, 6.4 and 10.6 g/kg, in 10 ml/kg body weight, by gavage) on the abdominal writhing response induced by intraperitoneal administration of acetic acid (0.8%, 10 ml/kg body weight) and on the tail immersion test was investigated in mice. Control animals received castor oil (10 ml/kg body weight) or saline (0.9% NaCl, 10 ml/kg body weight). CrEL reduced nociception in a dose-dependent manner in both... Tipo: Info:eu-repo/semantics/other Palavras-chave: Antinociception; Cremophor EL; Tail immersion test; Writhing test; Dipyrone; Morphine. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100016 Registros recuperados: 2 Primeira ... 1 ... Última

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