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	Provedor de dados BJMBR (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Albuquerque-Modesto,JC (1) Almeida,A.C. (1) Bezerra,G. (1) Fonteles,M.C. (1) Guarnieri,MC (1) Lima,A.A.M. (1) Martins,A.M.C. (1) Melo,ESL (1) Melo,KMS (1) Monteiro,H.S.A. (1) Nobre,A.C.L. (1) Prieto-da-Silva,ARB (1) Rádis-Baptista,G (1) Mais... Palavra-chave Crotalus durissus cascavella (2) Acidic PLA2 (1) CDNA library (1) Macrophage (1) Molecular toxinology (1) Nephrotoxicity (1) Pentoxifylline (1) Snake venom gland (1) Thalidomide (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2009 (1) 2004 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Cloning of a novel acidic phospholipase A2 from the venom gland of Crotalus durissus cascavella (Brazilian northeastern rattlesnake) J. Venom. Anim. Toxins incl. Trop. Dis. Guarnieri,MC; Melo,ESL; Melo,KMS; Albuquerque-Modesto,JC; Prieto-da-Silva,ARB; Rádis-Baptista,G. The phospholipase A2 superfamily encompasses 15 groups that are classified into: secreted PLA2 (sPLA2); cytosolic PLA2 (cPLA2); Ca2+-independent intracellular PLA2 (iPLA2); platelet-activating factor acetylhydrolase (PAF-AH); and lysosomal PLA2. Currently, approximately 700 PLA2 sequences are known, of which 200 are obtained from the venom gland of Crotalinae snakes. However, thus far, little information is available on cloning, purification and structural characterization of PLA2 from Crotalus durisssus cascavela venom gland. In the present work, we report the molecular cloning of a novel svPLA2 from C. d. cascavella (Cdc), a predominant rattlesnake subspecies in northeastern Brazil. The Cdc svPLA2 cDNA precursor is 689 nucleotides long and encodes a... Tipo: Info:eu-repo/semantics/article Palavras-chave: Molecular toxinology; Crotalus durissus cascavella; Snake venom gland; CDNA library; Acidic PLA2. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000400012 Thalidomide and pentoxifylline block the renal effects of supernatants of macrophages activated with Crotalus durissus cascavella venom BJMBR Martins,A.M.C.; Nobre,A.C.L.; Almeida,A.C.; Bezerra,G.; Lima,A.A.M.; Fonteles,M.C.; Monteiro,H.S.A.. Because thalidomide and pentoxifylline inhibit the synthesis and release of tumor necrosis factor-alpha (TNF-alpha), we determined the effect of these drugs on the renal damage induced by supernatants of macrophages activated with Crotalus durissus cascavella venom in order to identify the role of TNF-alpha in the process. Rat peritoneal macrophages were collected with RPMI medium and stimulated in vitro with C.d. cascavella venom (10 µg/ml) in the absence and presence of thalidomide (15 µM) or pentoxifylline (500 µM) for 1 h and washed and kept in culture for 2 h. Supernatant (1 ml) was tested on an isolated perfused rat kidney (N = 6 for each group). The first 30 min of each experiment were used as control. The supernatant was added to the perfusion... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nephrotoxicity; Crotalus durissus cascavella; Pentoxifylline; Thalidomide; Macrophage. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001000012 Registros recuperados: 2 Primeira ... 1 ... Última

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