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| Zhang,H.T.; Zhang,T.; Chai,M.; Sun,J.J.; Yu,X.Y.; Liu,C.Z.; Huang,C.C.. |
| Levels of hydrogen sulfide (H2S), a gaseous signaling molecule, are reduced in the serum of individuals who smoke. We hypothesized that tobacco smoke influenced smooth muscle relaxation by decreasing H2S levels and this effect could also influence expression of cystathionine γ-lyase (CSE) and sulfonylurea receptor-2 (SUR-2). The aim of this study was to explore the effect of tobacco smoke on H2S-mediated rat thoracic aorta relaxation and its possible mechanism. Thirty-two Sprague-Dawley rats were divided into four groups: control (C) group, short-term smoker (SS) group, mid-term smoker (MS) group, and long-term smoker (LS) group. H2S concentrations in serum, action of H2S on rat aortic vascular relaxation, and expression of CSE and SUR-2 in thoracic aortic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tobacco smoke; Hydrogen sulfide; Cardiac smooth muscle; Cystathionine-γ-lyase; Sulfonylurea receptor-2. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000200602 |
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| Sangali,Cleiton Pagliari; Gasparino,Eliane; Vasconcellos,Ricardo Souza; Fachinello,Marcelise Regina; Monteiro,Alessandra Nardina Trícia Rigo; Esteves,Lucas Antonio Costa; Bonagurio,Lucas Pimentel; Pozza,Paulo Cesar. |
| ABSTRACT This study was carried out to evaluate the effect of different levels of standardized ileal digestible (SID) methionine + cystine (Met+Cys) and vitamin B6 supplementation on the performance, blood variables, and gene expression of enzymes involved in methionine metabolism in female pigs between 75 and 100 kg. Fifty six female pigs were used (Talent × Topigs 20), averaging 75.06±1.68 kg in initial weight, allotted in a completely randomized block design arranged in a 2 × 4 factorial scheme, composed of two vitamin B6 supplementation levels (1.58 and 3.58 mg/kg) and four levels of SID Met+Cys (0.370, 0.470, 0.570, and 0.670%), with seven replicates and one animal per experimental unit. No interactions between vitamin B6 supplementation and SID... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Blood variable; Cystathionine-γ-lyase; Homocysteine; Methionine synthase; Performance; Pigs. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982017000300223 |
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