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Early HHV-6 replication is associated with morbidity non-related to CMV infection after kidney transplantation BJID
Schroeder,Regina Barbosa; Michelon,Tatiana Ferreira; Garbin,Gabriela; Garcia,Valter; Silveira,Janaina Gomes da; Santos,Luciano; Neumann,Jorge; Keitel,Elizete.
Human herpesvirus type 6-(HHV-6) has been associated with morbidity after liver transplantation. OBJECTIVE: The aim of this study was to determine the HHV-6 seroprevalence among donor-recipient pairs, analyze the incidence of early active infection, its clinical manifestation, interaction with CMV, and the related morbidity in the first year after kidney transplantation. METHODS: 46 donor-recipient pairs had IgG evaluated by ELISA before transplantation: HHV-6(Pambio - USA) and CMV-(Roche - USA). A frozen whole blood sample collected weekly (from the 1st to the 6th week) was retrospectively tested for HHV-6 viral load (VL) determination by real time quantitative PCR (qPCR, Nanogen - Italy). Patients were preemptively surveyed for CMV by pp65 antigenemia...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytomegalovirus infections; Herpesvirus 6/human; DNA virus infections; Clinical diagnosis; Polymerase chain reaction.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200007
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Cutaneous cytomegalovirus infection in a child with hyper IgE and specific defects in antibody response to protein vaccines BJID
Fallah,Shahrzad; Tabatabaei,Ahmad; Pournasir,Zahra; Chavoshzadeh,Zahra; Rezaei,Nima.
Cytomegalovirus (CMV) infection is a common opportunistic systemic infection in immunocompromised patients, but skin involvement is rare. Herein, we report a 10 year-old girl from consanguineous parents who was referred to our center because of disseminated maculopapular rash. She had history of upper and lower respiratory tract infections. In immunological studies, increased serum IgE level and decreased responses to tetanus and diphtheria were detected. Polymerase chain reaction (PCR) examination of bronchoalveolar lavage and serum sample revealed the presence of CMV. Early diagnosis of cutaneous CMV and appropriate treatment are the key actions in management of patients with underlying immunodeficiencies to avoid further complications.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Cytomegalovirus infections; Antibody formation; Common variable immunodeficiency.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500013
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