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| Contreras-Ortiz,José María Eloy; Vázquez-Chagoyán,Juan Carlos; Martínez-Castañeda,José Simón; Estrada-Franco,José Guillermo; Aparicio-Burgos,José Esteban; Acosta-Dibarrat,Jorge; Barbabosa-Pliego,Alberto. |
| Background : The venom of Centruroides limpidus limpidus (Cll) is a mixture of pharmacologically active principles. The most important of these are toxic proteins that interact both selectively and specifically with different cellular targets such as ion channels. Recently, anticancer properties of the venom from other scorpion species have been described. Studies in vitro have shown that scorpion venom induces cell death, inhibits proliferation and triggers the apoptotic pathway in different cancer cell lines. Herein, after treating human cervical adenocarcinoma (HeLa) cells with Cll crude venom, their cytotoxic activity and apoptosis induction were assessed. Results : Cll crude venom induced cell death in normal macrophages in a dose-dependent manner.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Scorpion venoms; Cytotoxic tests; Apoptosis; HeLa cells; Anticancer agents; Centruroides toxins. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100311 |
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