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	Provedor de dados BJMBR (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Chen,X.Q. (1) Chirino,Yolanda I (1) Jiang,X.Y. (1) Monroy-Estrada,Heidi I (1) Soria-Mercado,Irma E (1) Sánchez-Rodríguez,Judith (1) Xiao,J.B. (1) Xu,M. (1) Zhang,Y.W. (1) Mais... Palavra-chave Cytotoxicity assay (2) Caryophyllene oxide (1) Cisplatin efficacy (1) Cnidaria (1) HepG2 and H1299 carcinoma cell lines (1) Human lung cancer cells (1) Marchantia convoluta extract (1) Pharmacology (1) Phytol (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2013 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Cytotoxicity of Marchantia convoluta leaf extracts to human liver and lung cancer cells BJMBR Xiao,J.B.; Chen,X.Q.; Zhang,Y.W.; Jiang,X.Y.; Xu,M.. The cytotoxicity of three extracts (petroleum ether, ethyl acetate and n-butanol) from a plant used in folk medicine, Marchantia convoluta, to human non-small cell lung carcinoma (H1299) and liver carcinoma (HepG2) cell lines was tested. After 72-h incubation of lung and liver cancer cell cultures with varying concentrations of extracts (15 to 200 µg/mL), cytotoxicity was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and reported in terms of cell viability. The extracts that showed a significant cytotoxicity were subjected to gas chromatography-mass spectrometry analysis to identify the components. The ethyl acetate, but not the petroleum ether or n-butanol extract, had a significant cytotoxicity against lung and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Marchantia convoluta extract; Cytotoxicity assay; HepG2 and H1299 carcinoma cell lines; Phytol; Caryophyllene oxide. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600005 Toxins from the Caribbean sea anemone Bunodeopsis globulifera increase cisplatin-induced cytotoxicity of lung adenocarcinoma cells J. Venom. Anim. Toxins incl. Trop. Dis. Monroy-Estrada,Heidi I; Chirino,Yolanda I; Soria-Mercado,Irma E; Sánchez-Rodríguez,Judith. Background Lung cancer causes 1.4 million deaths worldwide while non-small-cell lung cancer (NSCLC) represents 80-85% of the cases. Cisplatin is a standard chemotherapy against this type of cancer; however, tumor cell resistance to this drug limits its efficacy. Sea anemones produce compounds with pharmacological activities that may be useful for augmenting cisplatin efficacy. This study aimed to evaluate the pharmacological activities of crude venom (CV) from the sea anemone Bunodeopsis globulifera and four derived fractions (F1, F2, F3 and F4) to test their increase efficiency cisplatin cytotoxicity in human lung adenocarcinoma cells. Results Pre-exposure to CV, F1 and F2 fractions increases cisplatin cytotoxicity in human lung adenocarcinoma cells under... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cnidaria; Pharmacology; Human lung cancer cells; Cytotoxicity assay; Cisplatin efficacy. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100308 Registros recuperados: 2 Primeira ... 1 ... Última

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