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	Provedor de dados BJMBR (1) Autor Campos,A.H. (1) Schor,N. (1) Palavra-chave Calcium oxalate (1) DCK cells (1) Mechanisms of endocytosis (1) Renal stone (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2000 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Mechanisms involved in calcium oxalate endocytosis by Madin-Darby canine kidney cells BJMBR Campos,A.H.; Schor,N.. Calcium oxalate (CaOx) crystals adhere to and are internalized by tubular renal cells and it seems that this interaction is related (positively or negatively) to the appearance of urinary calculi. The present study analyzes a series of mechanisms possibly involved in CaOx uptake by Madin-Darby canine kidney (MDCK) cells. CaOx crystals were added to MDCK cell cultures and endocytosis was evaluated by polarized light microscopy. This process was inhibited by an increase in intracellular calcium by means of ionomycin (100 nM; N = 6; 43.9% inhibition; P<0.001) or thapsigargin (1 µM; N = 6; 33.3% inhibition; P<0.005) administration, and via blockade of cytoskeleton assembly by the addition of colchicine (10 µM; N = 8; 46.1% inhibition;... Tipo: Info:eu-repo/semantics/article Palavras-chave: Calcium oxalate; DCK cells; Mechanisms of endocytosis; Renal stone. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100015 Registros recuperados: 1 Primeira ... 1 ... Última

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