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	Provedor de dados Biol. Res. (1) BJMBR (1) BJM (1) Genet. Mol. Biol. (1) Autor Amaral,F.G. (1) Berra,C.M. (1) Bordin,S. (1) Cipolla-Neto,J. (1) Curi,R. (1) Dang,Nguyen Hai (1) Dat,Nguyen Tien (1) Deepak,Venkataraman (1) Dianovsky,Ján (1) Ferreira,S.G. (1) Gurunathan,Sangiliyandi (1) Holecková,Beáta (1) Hung,Tran Manh (1) Kalishwaralal,Kalimuthu (1) Pandian,Sureshbabu Ram Kumar (1) Peliciari-Garcia,R.A. (1) Rodrigues,A.C. (1) Siviková,Katarína (1) Takahashi-Hyodo,S.A. (1) Viswanathan,Pushpa (1) Mais... Palavra-chave DNA fragmentation (4) Apoptosis (1) Bacillus licheniformis (1) Caesalpinia sappan (1) Caspase-3 (1) Chromosomal aberration (1) Comet assay (1) Cyclophosphamide (1) Leguminosae (1) MTT assay (1) Melatonin (1) Nanoparticle synthesis (1) Silver nitrate (1) Sister chromatid exchanges (1) Tolylfluanid-based fungicide (1) Xpf expression (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Journal article (1) Ano 2014 (1) 2013 (1) 2011 (1) 2010 (1) País Brazil (3) Chile (1) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Induction of SCEs and DNA fragmentation in bovine peripheral lymphocytes by in vitro exposure to tolylfluanid-based fungicide Genet. Mol. Biol. Siviková,Katarína; Dianovsky,Ján; Holecková,Beáta. The potential for genotoxic and cytotoxic effects of tolylfluanid-based fungicide (50% active agent) was evaluated using sister chromatid exchange (SCE) and proliferation indices (PI) in cultured bovine peripheral lymphocytes. For the detection of possible genetic damage, DNA fragmentation assay was also applied. Bovine lymphocytes cultured for 72 h were treated with the fungicide at the final concentrations of 1.75, 3.5, 8.75, and 17.5 µg/mL for the last 24 and 48 h of culture without S9 metabolic activation, and during the last 2 h of culture with S9 metabolic activation. In the SCE assays no evidence for genotoxic activity of the fungicide was found in treatments of 24 h without and 2 h with S9. After the 24 h exposure to tolylfluanid, a weak decrease... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tolylfluanid-based fungicide; Sister chromatid exchanges; DNA fragmentation. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100019 Methanol extract from Vietnamese Caesalpinia sappan induces apoptosis in HeLa cells Biol. Res. Hung,Tran Manh; Dang,Nguyen Hai; Dat,Nguyen Tien. BACKGROUND: This study evaluated the cytotoxic activity of extracts from Caesalpinia sappan heartwood against multiple cancer cell lines using an MTT cell viability assay. The cell death though induction of apoptosis was as indicated by DNA fragmentation and caspase-3 enzyme activation. RESULTS: A methanol extract from C. sappan (MECS) showed cytotoxic activity against several of the cancer cell lines. The most potent activity exhibited by the MECS was against HeLa cells with an IC50value of 26.5 ± 3.2 µg/mL. Treatment of HeLa cells with various MECS concentrations resulted in growth inhibition and induction of apoptosis, as indicated by DNA fragmentation and caspase-3 enzyme activation. CONCLUSION: This study is the first report of the... Tipo: Journal article Palavras-chave: Caesalpinia sappan; Leguminosae; MTT assay; DNA fragmentation; Caspase-3. Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100020 Effects of melatonin on DNA damage induced by cyclophosphamide in rats BJMBR Ferreira,S.G.; Peliciari-Garcia,R.A.; Takahashi-Hyodo,S.A.; Rodrigues,A.C.; Amaral,F.G.; Berra,C.M.; Bordin,S.; Curi,R.; Cipolla-Neto,J.. The antioxidant and free radical scavenger properties of melatonin have been well described in the literature. In this study, our objective was to determine the protective effect of the pineal gland hormone against the DNA damage induced by cyclophosphamide (CP), an anti-tumor agent that is widely applied in clinical practice. DNA damage was induced in rats by a single intraperitoneal injection of CP (20 or 50 mg/kg). Animals received melatonin during the dark period for 15 days (1 mg/kg in the drinking water). Rat bone marrow cells were used for the determination of chromosomal aberrations and of formamidopyrimidine DNA glycosylase enzyme (Fpg)-sensitive sites by the comet technique and ofXpf mRNA expression by qRT-PCR. The number (mean ± SE) of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Melatonin; Cyclophosphamide; Chromosomal aberration; DNA fragmentation; Comet assay; Xpf expression. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300278 Mechanism of bactericidal activity of Silver Nitrate - a concentration dependent bi-functional molecule BJM Pandian,Sureshbabu Ram Kumar; Deepak,Venkataraman; Kalishwaralal,Kalimuthu; Viswanathan,Pushpa; Gurunathan,Sangiliyandi. Silver nitrate imparts different functions on bacteria depending upon its concentration. At lower concentration it induced synthesis of nanoparticles, whereas at higher concentrations it induced cell death. Bacillus licheniformis was used as model system. The MIC was 5 mM, and it induced catalase production, apoptotic body formation and DNA fragmentation. Tipo: Info:eu-repo/semantics/article Palavras-chave: Silver nitrate; Bacillus licheniformis; Nanoparticle synthesis; Apoptosis; DNA fragmentation. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000300033 Registros recuperados: 4 Primeira ... 1 ... Última

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