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| Dhalia,Rafael; Maciel Jr.,Milton; Cruz,Fábia S.P.; Viana,Isabelle F.T.; Palma,Mariana L.; August,Thomas; Marques Jr.,Ernesto T.A.. |
| Vaccination is the most practical and cost-effective strategy to prevent the majority of the flavivirus infection to which there is an available vaccine. However, vaccines based on attenuated virus can potentially promote collateral side effects and even rare fatal reactions. Given this scenario, the developent of alternative vaccination strategies such as DNA-based vaccines encoding specific flavivirus sequences are being considered. Endogenous cytoplasmic antigens, characteristically plasmid DNA-vaccine encoded, are mainly presented to the immune system through Major Histocompatibility Complex class I - MHC I molecules. The MHC I presentation via is mostly associated with a cellular cytotoxic response and often do not elicit a satisfactory humoral... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dengue; West Nile; Yellow fever; Lysosome-Associated Membrane Protein - LAMP; DNA vaccines. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000400005 |
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