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	Provedor de dados BJMBR (1) Autor Shen,J.C. (1) Zhang,Y.C. (1) Zhao,M.F. (1) Palavra-chave Bone marrow (1) Deferasirox (1) Hematopoietic stem/progenitor cells (1) Iron overload (1) N-acetyl-L-cysteine (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow BJMBR Shen,J.C.; Zhang,Y.C.; Zhao,M.F.. Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-administered with iron dextran in two groups of mice (Fe+DFX and Fe+NAC), and the function of HSPCs was then examined. Iron overload markedly decreased the number of murine HSPCs in bone marrow. Subsequent colony-forming cell assays showed that iron overload also decreased the colony forming capacity of HSPCs, the effect of which could be reversed by DFX and NAC. The bone marrow hematopoiesis damage... Tipo: Info:eu-repo/semantics/article Palavras-chave: Iron overload; Bone marrow; Hematopoietic stem/progenitor cells; Deferasirox; N-acetyl-L-cysteine. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200613 Registros recuperados: 1 Primeira ... 1 ... Última

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