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	Provedor de dados 56 (2) Autor Bohrer,D. (1) Bonan,C.D. (1) Garcia,R.C. (1) Giacomelli,M.B.O. (1) Goulart,E.C. (1) Morsch,V.M. (1) Pereira,C.A.T. (1) Rodrigues,A.L.S. (1) Rodrigues,S.R. (1) Schetinger,M.R.C. (1) Valentim,L.M. (1) Mais... Palavra-chave Delta-aminolevulinate dehydratase (2) Aluminum determination (1) Aluminum sulfate (1) Lead acetate (1) Negative geotaxis (1) Postnatal brain growth (1) Zinc chloride (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2001 (1) 1999 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effects of lead and/or zinc exposure during the second stage of rapid postnatal brain growth on delta-aminolevulinate dehydratase and negative geotaxis of suckling rats 56 Goulart,E.C.; Pereira,C.A.T.; Garcia,R.C.; Giacomelli,M.B.O.; Rodrigues,A.L.S.. Lead has been shown to produce cognitive and motor deficits in young rats that could be mediated, at least in part, by inhibition of the zinc-containing heme biosynthetic enzyme delta-aminolevulinate dehydratase (ALA-D). In the present study we investigated the effects of lead and/or zinc treatment during the second stage of rapid postnatal brain development on brain, kidney and blood ALA-D specific activity, as well as the negative geotaxis behavior of rats. Eight-day-old Wistar rats were injected intraperitoneally with saline, lead acetate (8 mg/kg) and/or zinc chloride (2 mg/kg) daily for five consecutive days. Twenty-four hours after treatment, ALA-D activity was determined in the absence and presence of DL-dithiothreitol (DTT). The negative geotaxis... Tipo: Info:eu-repo/semantics/other Palavras-chave: Lead acetate; Zinc chloride; Delta-aminolevulinate dehydratase; Negative geotaxis; Postnatal brain growth. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600014 Effects of aluminum sulfate on delta-aminolevulinate dehydratase from kidney, brain, and liver of adult mice 56 Schetinger,M.R.C.; Bonan,C.D.; Morsch,V.M.; Bohrer,D.; Valentim,L.M.; Rodrigues,S.R.. The purpose of the present study was to investigate the in vitro and in vivo effects of aluminum sulfate on delta-aminolevulinic acid dehydratase (ALA-D) activity from the brain, liver and kidney of adult mice (Swiss albine). In vitro experiments showed that the aluminum sulfate concentration needed to inhibit the enzyme activity was 1.0-5.0 mM (N = 3) in brain, 4.0-5.0 mM (N = 3) in liver and 0.0-5.0 mM (N = 3) in kidney. The in vivo experiments were performed on three groups for one month: 1) control animals (N = 8); 2) animals treated with 1 g% (34 mM) sodium citrate (N = 8) and 3) animals treated with 1 g% (34 mM) sodium citrate plus 3.3 g% (49.5 mM) aluminum sulfate (N = 8). Exposure to aluminum sulfate in drinking water inhibited ALA-D activity in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aluminum sulfate; Aluminum determination; Delta-aminolevulinate dehydratase. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600012 Registros recuperados: 2 Primeira ... 1 ... Última

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