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Estudio etnofarmacológico de especies vegetales con actividad hipoglucemiante en la comunidad de Malpasito en Huimanguillo, Tabasco. Colegio de Postgraduados
Villarreal Ibarra, Edelia Claudina.
Ante el incremento de enfermedades crónico-degenerativas uno de los recursos terapéuticos por excelencia lo representa la medicina tradicional, la presente investigación documenta y evalúa farmacológicamente las plantas utilizadas para el control de la Diabetes Mellitus (DM) en la comunidad de Malpasito, dentro de la Reserva Ecológica de Agua Selva en Huimanguillo, Tabasco, México como un aporte a la validación científica. Registra un inventario del conocimiento tradicional de las plantas medicinales, con información sobre el uso terapéutico, forma de preparación y parte vegetal utilizada. La información se recabó mediante entrevistas estructuradas TRAMIL. Se registraron 128 especies distribuidas en 63 familias botánicas, los usos medicinales se agruparon...
Palavras-chave: Medicina tradicional; Diabetes; Citotoxicidad; Artemia salina; Traditional medicine; Cytotoxicity; Ciencias por Investigación; Doctorado.
Ano: 2014 URL: http://hdl.handle.net/10521/2278
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The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population Genet. Mol. Biol.
Cimponeriu,Danut; Apostol,Pompilia; Radu,Irina; Craciun,Anne Marie; Serafinceanu,Cristian; Toma,Mihai; Panaite,Cristian; Cheta,Dan.
The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Insulin -23Hph; Insulin-like growth factor 2 Apa; Diabetes; Obesity; Case-control study.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400003
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O cultivo de yacon no Brasil Horticultura Brasileira
Vilhena,Stela Maria C; Câmara,Francisco Luiz A; Kakihara,Sergio T.
O yacon (Polymnia sonchifolia Poep. Endl.) é uma espécie da família Asteraceae que apresenta um complexo sistema subterrâneo. Suas raízes tuberosas e rizóforos contêm grandes quantidades de frutose e glicose livres, além de fruto-oligossacarídeos do tipo inulina como carboidrato de reserva. Vem despertando interesse principalmente por suas propriedades medicinais, sendo utilizado como auxiliar no tratamento contra diabetes e colesterol. Foi introduzido no Brasil por volta de 1989, porém somente em 1994 iniciaram-se os primeiros cultivos comerciais. Atualmente é cultivado na região de Capão Bonito (SP), a partir de rizóforos pesando de 60 a 80 g. Estes são plantados em canteiros de 0,30 - 0,40 m de altura por 1,0 m de base, em um espaçamento de 1,00 x 0,90...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Polymnia sonchifolia Poep. Endl; Carboidratos de reserva; Diabetes; Sistema de produção; Pós-colheita.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-05362000000100002
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Diabetic Peripheral Neuropathies: A Morphometric Overview International Journal of Morphology
Fazan,Valéria Paula Sassoli; Vasconcelos,Carlos Augusto Carvalho de; Valença,Marcelo Moraes; Nessler,Randy; Moore,Kenneth Charles.
Diabetes is now considered one of the main threats to human health in the 21st century and many researchers are dedicated to investigate the physiopathology of the disease, with further insights on the managements of its major complications. Since understanding the pathophysiology of the major complications of diabetes and their underlying processes is mandatory, experimental models of the disease may be useful as they allow the recognition of the early mechanisms involved in the long-term complications of diabetes. Peripheral nerve involvement is highly frequent in diabetes mellitus and it has been documented that one third of diabetic patients have peripheral neuropathy. The true prevalence is not known and reports vary from 10% to 90% in diabetic...
Tipo: Journal article Palavras-chave: Diabetes; Experimental models; Neuropathy; Morphometry.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100007
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Tribulus terrestris Hydroalcoholic Extract Administration Effects on Reproductive Parameters and Serum Level of Glucose in Diabetic Male Rats International Journal of Morphology
Ghanbari,Ali; Moradi,Mojtaba; Raoofi,Amir; Falahi,Mahsa; Seydi,Sepideh.
Usage of medicinal plants for the treatment of diseases is a remarkable strategy considered in both clinical and experimental studies. This study was conducted to evaluate the effect of Tribulus terrestris hydroalcoholic extract administration on the serum level of glucose and reproductive parameters in diabetic male rats. In this experimental study, 30 adult male Wistar rats (200­250 g) were divided into 5 groups (n= 6). Diabetes was induced by a single intraperitoneal injection of 50 mg/kg streptozotocin. Experimental groups received daily Intraperitoneal injection of the extract (100, 250 and 500 mg/kg) since one week after inducing diabetes for two weeks. At the end of the experiment, the serum levels of testosterone and glucose were examined by ELISA...
Tipo: Journal article Palavras-chave: Diabetes; Glucose; Rat; Streptozotocin; Testosterone; Tribulus terrestris.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200058
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Metformin Induces Ultrastructural Alterations in Hepatocytes of Spontaneously Hypertensive Rats International Journal of Morphology
Gharbaran,Rajendra.
Metformin, an oral biguanide approved for the treatment of type II diabetes is widely prescribed for other clinical conditions. Currently, metformin is being investigated as potential anti-tumor agent. However, there have been recent concerns about hepatotoxicity associated with the use of metformin. This study, by means of high resolution transmission electron microscopy (TEM) and morphometry, investigated potential ultrastructural changes induced by metformin treatment on the hepatocytes of spontaneously hypertensive rats (SHR). Morphometric analysis was carried out on images of randomly selected cells from sectioned gluteraldehyde-osmium-fixed, Epon embedded liver tissue. One-way analysis of variance (ANOVA) on morphometric data showed statistically...
Tipo: Journal article Palavras-chave: Metformin; Rats; TEM; Cancer; Diabetes.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300016
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Protective Effect of Alcoholic Extract of Garden Cress Seeds on the Histopathological Changes of the Ventral Prostate in Streptozotocin Diabetic Rats International Journal of Morphology
Kamani,Mehran; Mhabadi,Javad Amini; Atlasi,Mohammad Ali; Seyedi,Fatemeh; Kamani,Emran; Nikzad,Hossein.
Diabetes mellitus is a common serious metabolic illness occurring worldwide that may lead to male infertility. Various plants have been used in the treatment of diabetes. In this study, the effect of garden cress (Lepidium sativum) seed extract on fasting blood sugar is assessed for its protective effect on histopathological changes in the ventral prostate gland of streptozotocine-induced diabetic rats. Fifty adult male Wistar rats were randomly selected into five groups. Group 1 was the control placebo group where rats received only 0.1 mL normal saline via gastric gavages. Rats in Group 2 received an intraperitoneal injection of STZ 60 mg/kg body weight and those with FBS >250 mg/dL were considered diabetic. In Group 3, diabetic rats received insulin...
Tipo: Journal article Palavras-chave: Diabetes; Prostate; Garden cress; Histological parameters.
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300057
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The Preventive and Treatment Effect of Urtica dioica on Astrocyte Density in the CA1 and CA3 Subfields of Hippocampus in STZ Induced Diabetic Rats International Journal of Morphology
Golalipour,Mohammad Jafar; Jahanshahi,Mehrdad; Ghafari,Soraya; Afshar,Mohammad.
Several animal model studies have shown that Diabetes mellitus can affect on the activity of hippocampus astrocytes, but these studies reported controversial findings. This study was done to evaluate the preventive and treatment effect of Urtica dioica (U. dioica) on astrocytes density in the CA1 and CA3 subfields of hippocampus of streptozotocin (STZ) induced diabetic rats. Twenty-eight male albino Wistar rats were randomly allocated equally into control, diabetic, U. dioica treatment and U. dioica preventive groups. Hyperglycemia was induced by STZ (80 mg/kg/BW). One week after injection of the streptozotocin, animals in treatment group were received hydroalcoholic extract of U. dioica (100 mg/kg/BW /day) for 4 weeks by intraperitoneally. In preventive...
Tipo: Journal article Palavras-chave: Diabetes; Astrocyte; Urtica dioica; Hippocampus; CA1; CA3; Rat.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200057
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The Effect of Walnut on the Weight, Blood Glucose and Sex Hormones of Diabetic Male Rats International Journal of Morphology
Ghorbani,R; Mokhtari,T; Khazaei,M; Salahshoor,M. R; Jalili,C; Bakhtiari,M.
Diabetes leads to reproductive dysfunctions by producing free radicals. It seems that using walnut can be effective in the damage induced by diabetes. The aim of the present study was to evaluate the effects of walnut consumption on sex hormones in diabetic Wistar male rats induced by STZ (streptozotocin). Diabetes animals were induced by STZ (60 mg/kg). Rats were randomly divided into 5 groups (n=6), including normal diet and healthy (Sham), Diabetic by normal diet (control) and diabetic by 6, 9 and 12% walnut in their diet (experimental groups), and were examined for 6 weeks. Body weight, blood glucose (3 times), and sex hormones (testosterone, FSH and LH) were measured. Overall, in terms of the mean index, there was a significant difference in the...
Tipo: Journal article Palavras-chave: Walnut; Diabetes; Weight; Blood glucose; Sex hormones.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300015
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Does Diabetes Alter Immunolocalization of Galectin-1 and Galectin-3 in the Rat Ovary? International Journal of Morphology
Özdenoglu,Berna; Saraydin,Serpil Ünver.
Diabetes mellitus (DM), is a metabolic disease occurring via insulin secretion deficiency from the pancreas and/or an insufficiency of tissue response to insulin. The present study is intended to show of immunolocalizations of beta-galactose-binding proteins Galectin-1 and Galectin-3 in diabetic rat ovarium and their relationship with diabetes. In this study, 8 to 10-week-old, 250­300 g weighing 50 mature female rats were used, in order to establish diabetes mellitus in those animals, 60 mg/kg intravenous streptozotocin was injected to each animal. After death, diabetics and non-diabetics rats's routine tissue processing steps is done to rat ovarial tissues for immunohistochemical investigation. Strong expressions of Galectin-1 and Galectin-3 were observed...
Tipo: Journal article Palavras-chave: Galectin-1; Galectin-3; Ovary; Diabetes; Rat.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200050
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Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica International Journal of Morphology
Golalipour,Mohammad Jafar; Ghafari,Soraya; Latifimoghadam,Mohammad Hossein; Kaboli,Sakineh.
Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. Therefore, this study was done to evaluate the protective effect of Urtica dioica on astrocytes density of the dentate gyrus in STZ induced diabetic rats. In this experimental study, 21 male albino Wistar rats were randomly allocated equally into normal, diabetic and protective (nettle treated diabetic) groups. Hyperglycemia was induced by streptozotocin (80 mg/kg) in the animals of diabetic and treatment groups. Before induction of diabetes in animals, animals in protective group received hydroalcoholic extract of Urtica dioica (100 mg/kg/BW /day) for five days...
Tipo: Journal article Palavras-chave: Diabetes; Astrocyte; Urtica dioica; Dentate gyrus.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400039
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Protective Effect of Lepidium sativum Seed Extract on Histopathology and Morphology of Epididymis in Diabetic Rat Model International Journal of Morphology
Kamani,Mehran; Hosseini,Elahe Seyed; Kashani,Hamed Haddad; Atlasi,Mohammad Ali; Nikzad,Hossein.
Diabetes mellitus is a frequent and serious metabolic illness all over the world and plants have been a desirable source of medicine recently. Diabetes has unpleasant effect on male reproductive system and it may lead to male infertility. It causes erectile dysfunction and reduces ejaculate volume by affecting the health of small blood vessels and the small nerves that control ejaculation and also decreases libido by decreasing testosterone levels. Current study evaluated the possible protective efficiency of Lepidium sativum (Garden cress) seed extract on fasting blood sugar (FBS) and then assessed histopathological change of epididymis in streptozotocine (STZ)-induced diabetic rats. We randomly categorized 50 adult male Wistar rats into five groups (each...
Tipo: Journal article Palavras-chave: Diabetes; Epididymis; Lepidium sativum (garden cress); Streptozotocine; Insulin.
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200036
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Histological and Histochemical Studies of the Aorta and Pulmonary Trunk in STZ-induced Diabetic Wistar Rats Treated with Momordica charantia International Journal of Morphology
Komolafe,O. A; Ofusori,D. A; Adewole,O. S; Ayoka,A. O; Bejide,R.
Diabetes mellitus (DM) is a serious metabolic disorder with micro and macro-vascular complications that result in a significant morbidity and mortality. The present study investigated the effects of Momordica charantia (M. charantia) on histological changes of the aorta and pulmonary trunk in streptozotocin-induced diabetic Wistar rats. Forty healthy adult Wistar rats of both sexes were randomly assigned into five groups A, B, C, D and E of eight rats each. Group A were the control (normal rats); B were the experimentally-induced diabetic rats; C were diabetic rats treated with methanolic extracts of M. charantia for two weeks (withdrawal group); D were diabetic rats treated with methanolic extracts of M. charantia for four weeks. E was diabetic rats...
Tipo: Journal article Palavras-chave: Diabetes; Momordica charantia; Histological; Histochemistry; Aorta; Pulmonary trunk.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200060
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Resistance of CA1 Pyramidal Cells to STZ-Induced Diabetes in Young Rats International Journal of Morphology
Fazeli,Seyyed Amirhossein; Gharravi,Anneh Mohammad; Jahanshahi,Mehrdad; Ghafari,Soraya; Behnampour,Naser; Golalipour,Mohammad Jafar.
The pyramidal cell density of CA1 hippocampal subfield following STZ-induced diabetes in young rats were studied. 12 male albino 6-week Wistar rats were allocated equally in groups of normal and diabetic. Hyperglycemia induced by Streptozotocin (80 mg/kg) in animals of diabetic group. After 5 weeks of study, all the rats were sacrificed and coronal sections were taken from dorsal hippocampal formation of the right cerebral hemispheres and stained with crysel violet. The area densities of the CA1 pyramidal cells were measured and compared among two groups. No significant difference between the densities of two experimental groups was found. The results can arise from the short period of diabetes and also the possible regenerative processes in developing...
Tipo: Journal article Palavras-chave: Pyramidal cell density; CA1; Hippocampus; Diabetes; Rat.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400006
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Proliferation of the b -Cells of Pancreas in Diabetic Rats Treated with Urtica Dioica International Journal of Morphology
Golalipour,Mohammad Jafar; Ghafari,Soraya; Kouri,Vahid; Kestkar,Abbas Ali.
This investigation was carried out to evaluate the effect of the extract of Urtica dioica leaves on hyperglycemia and quantitative changes of b-cells in streptozotocin-diabetic rats. Forty male Wistar rats were allocated in groups of normal, diabetic, treatment and protective. Hyperglycemia induced by administrating one dose of 80 mg/kg streptozotocin (STZ) intraperitoneally. Animals in treatment group received Urtica dioica (100 mg/kg/day) for 4 weeks intraperitoneally, one week after injection of STZ. In protective group animals received U. dioica (100 mg/kg/day) for 5 days before inducing diabetes. After five weeks the animals were sacrificed and whole pancreas removed. Pancreas specimens were used for quantitative morphometric analysis after Chromealum...
Tipo: Journal article Palavras-chave: Streptozotocin; Diabetes; Urtica dioica; Rat; Pancreas; B-cells; Blood glucose.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200011
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Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats International Journal of Morphology
Golalipour,Mohammad Jafar; Ghafari,Soraya; Farsi,Mir Mehrdad.
Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative morphometric changes in parenchymal cells of the livers in STZ diabetic rats. Thirty male Wistar rats were allocated in 3 groups: normal, diabetic and treatment. Hyperglycemia was induced by 80 mg/kg Streptozotocin intraperitoneally. One week after the injection of STZ, the third group received the hydroalcoholic extract of Urtica dioica at 100 mg/kg/day over four weeks. After five weeks, the animals were sacrificed and whole livers were removed. Liver specimens were used for quantitative morphometric analyze...
Tipo: Journal article Palavras-chave: Diabetes; Urtica dioica; Liver; Hepatocyte; Morphometry.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400058
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Propolis effect on streptozotocin-induced diabetic rats J. Venom. Anim. Toxins incl. Trop. Dis.
Sartori,DRS; Kawakami,CL; Orsatti,CL; Sforcin,JM.
Propolis is one of the hive products that has been used extensively in folk medicine, due to its several biological and pharmacological properties. Besides, propolis-containing products have been intensely marketed by the pharmaceutical industry and health-food stores. This work was carried out in order to investigate whether propolis treatment could revert the metabolic alterations of streptozotocin-induced diabetic rats. Animals were kept in metabolic cages and diabetes was induced by a single dose of streptozotocin (35 mg/kg, IV). After a week, rats with glycemia higher than 230 mg/dL were divided into two groups and treated with ethanolic extract of propolis (10 and 90 mg/kg, PO) for seven days. Glycemia and free fatty acids were determined, as well as...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Brazilian propolis; Diabetes; Glucose; Free fatty acids.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100009
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Local Food Impacts on Health and Nutrition AgEcon
Ferrer, Myra Clarisse R.; Fonsah, Esendugue Greg; Ramirez, Octavio A.; Escalante, Cesar L..
Prevalence of local foods is believed to answer several food issues one of which is health and nutrition. This study focused on the on the availability of local foods to consumers and see its relationship with two specific diet-related diseases namely, obesity and diabetes. Other variables were included in the analysis to provide additional evidence to previous findings. Factors considered are divided into 5 groups namely diet-, local food-, environment-, education- and gender-related factors. Diet- and environment-related variables provide the most perceptive findings while local food variables provided significant however weak evidence of positive impacts to health and nutrition.
Tipo: Conference Paper or Presentation Palavras-chave: Local foods; Diabetes; Obesity; Food environment; Farmers' market; Agricultural and Food Policy; Consumer/Household Economics; Food Consumption/Nutrition/Food Safety; Health Economics and Policy; I15; I31.
Ano: 2011 URL: http://purl.umn.edu/103664
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Obesity and Diabetes, the Built Environment, and the 'Local' Food Economy AgEcon
Salois, Matthew J..
Obesity and diabetes are increasingly attributed to environmental factors, however, little attention has been paid to the influence of the ‘local’ food economy. This paper examines the association of measures relating to the built environment and ‘local’ agriculture with U.S. county-level prevalence of obesity and diabetes. Key indicators of the ‘local’ food economy include the density of farmers’ markets and the presence of farms with direct sales. This paper employs a robust regression estimator to account for non-normality of the data and to accommodate outliers. Overall, the built environment is associated with the prevalence of obesity and diabetes and a strong 'local' food economy may play an important role in prevention. Results imply considerable...
Tipo: Conference Paper or Presentation Palavras-chave: Community-intervention; Diabetes; Food environment; Famers’ market; Leverage points; ‘local’ food; Robust regression; Obesity; Outliers.; Agricultural and Food Policy; Food Consumption/Nutrition/Food Safety; Health Economics and Policy.
Ano: 2011 URL: http://purl.umn.edu/103649
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Great discoveries of milk for a healthy diet and a healthy life R. Bras. Zootec.
Palmquist,Donald L..
Extensive research in recent years has shown that consumption of milk and dairy products, promotes cardiovascular health, reduces symptoms of the metabolic syndrome in obese individuals, promotes weight loss while maintaining body muscle mass and reduces incidence of some cancers. Detailed analysis of prospective studies in large Western populations over long periods of time demonstrates that higher consumption of dairy products provides an overall survival advantage.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; Cardiovascular health; Diabetes; Healthy diets; Milk.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982010001300051
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