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The mechanism of drug interactions of a selected antiarrhythmic drug with metformin, in different animal models BJPS
Khan,Kayamkani Abedulla; Satyanarayana,Sreemantula; Kumar,Kilari Eswar.
ABSTRACT This study was carried out to understand the influence of a selected antiarrhythmic drug on the pharmacodynamics and pharmacokinetics of an antidiabetic drug in animal models. Pharmacodynamic and pharmacokinetic responses were determined by measurements of blood glucose and serum insulin and serum metformin to drug interactions between disopyramide and metformin. Single dose and multi dose studies showed that the maximum blood glucose reductions in normal and diabetic rats were at the 6th hour, and in rabbits at the 3rd hour. Glucose-insulin homeostasis was evaluated to assess the safety and effectiveness of the combination. There was a marginal increase in the pharmacokinetic parameters of metformin with multiple dose treatments of disopyramide...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Disopyramide/pharmacokinetic interactions/pharmacodynamic; Metformin/ pharmacokinetic interactions/pharmacodynamic; Drug Interactions; Hypoglycaemia; Diabetes mellitus..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400601
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