Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJMBR (2) Autor Antunes-Rodrigues,J. (1) Brown,J.W. (1) Fishman,L.M. (1) Picanço-Diniz,D.L.W. (1) Valença,M.M. (1) Palavra-chave Dibutyryl cAMP (2) ACTH (1) Adrenal carcinoma (1) Cell culture (1) Cholera toxin (1) Cyclopentyltheophylline (1) Krebs cycle intermediates (1) Metyrapone (1) Pertussis toxin (1) R-PIA (1) Steroids (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2006 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Adenosine A1 receptor-mediated inhibition of in vitro prolactin secretion from the rat anterior pituitary BJMBR Picanço-Diniz,D.L.W.; Valença,M.M.; Antunes-Rodrigues,J.. In previous studies, we demonstrated biphasic purinergic effects on prolactin (PRL) secretion stimulated by an adenosine A2 agonist. In the present study, we investigated the role of the activation of adenosine A1 receptors by (R)-N6-(2-phenylisopropyl)adenosine (R-PIA) at the pituitary level in in vitro PRL secretion. Hemipituitaries (one per cuvette in five replicates) from adult male rats were incubated. Administration of R-PIA (0.001, 0.01, 0.1, 1, and 10 µM) induced a reduction of PRL secretion into the medium in a U-shaped dose-response curve. The maximal reduction was obtained with 0.1 µM R-PIA (mean ± SEM, 36.01 ± 5.53 ng/mg tissue weight (t.w.)) treatment compared to control (264.56 ± 15.46 ng/mg t.w.). R-PIA inhibition (0.01 µM = 141.97 ± 15.79... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cyclopentyltheophylline; Dibutyryl cAMP; R-PIA; Pertussis toxin; Cholera toxin. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001100013 Biosynthesis and metabolism of steroid hormones by human adrenal carcinomas BJMBR Brown,J.W.; Fishman,L.M.. Over a 15-year period, our university-based laboratory obtained 125 adrenal tumors, of which 15 (12%) were adrenal cortical carcinomas. Of these, 6 (40% of the carcinomas) occurred in patients with clear clinical manifestations of steroid hormone excess. Adrenal cortical carcinoma cells derived from the surgically resected tumors in 4 of these patients were isolated and established in primary culture. Radiotracer steroid interconversion studies were carried out with these cultures and also on mitochondria isolated from homogenized tissues. Large tumors had the lowest steroidogenic activities per weight, whereas small tumors had more moderately depressed enzyme activities relative to cells from normal glands. In incubations with pregnenolone as substrate, 1... Tipo: Info:eu-repo/semantics/article Palavras-chave: Adrenal carcinoma; Cell culture; Steroids; Metyrapone; Dibutyryl cAMP; ACTH; Krebs cycle intermediates. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000014 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco