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| García Delgado,Neivys; Frías Vázquez,Ana Iris; Cabrera Sánchez,Hiran; Soto del Valle,Roberto Menéndez; Sierra Gómez,Yusvel; Suárez Alfonso,Ana María. |
| The aim of the present work was to investigate the anti-inflammatory and antinociceptive effects of methanolic extract from D. obtusata using classic models in mice (croton oil-induced ear edema and acetic acid-induced writhing) and a phospholipase A2 activity test. Qualitative analysis of the chemical composition of seaweed was also determined by extraction with solvents of increasing polarity and precipitation and color tests. Results of qualitative chemical study showed the presence of lactonic and phenolic compounds, reduced carbohydrates, other sugars, flavonoids, fatty compounds, triterpenes and steroids. The extract inhibited mouse ear edema in a dose-dependent manner with an efficacy higher than 90% and a mean effective dose of 4.87µg/ear, while... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dichotomaria obtusata/pharmacognosy; Dichotomaria obtusata/anti-inflammatory activity; Dichotomaria obtusata/antinociceptive activity; Mouse ear edema test; Writhing test. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100008 |
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| Vázquez,Ana Iris Frías; Sánchez,Carlos Manuel Dutok; Delgado,Neivys García; Alfonso,Ana María Suarez; Ortega,Yúlica Santos; Sánchez,Hiran Cabrera. |
| The aim of the present work was to investigate the anti-inflammatory and analgesic effects of red seaweed Dichotomaria obtusata, using classic tests in mice (ear edema induced by TPA and writhing induced by acetic acid). The qualitative chemical composition of the aqueous extract (lactones, phenols, triterpenes, steroids and reduced carbohydrates) obtained from this alga was also determined. The results showed that Dichotomaria obtusata (12.5, 25 and 50 mg/kg, ip) inhibited mouse ear edema in a dose-dependent manner. In the writhing test, aqueous extract (12.5, 25, 50 and 100 mg/kg, ip and 100, 200, 400, 800 mg/kg, po) significantly reduced abdominal writhes. In conclusion, this study demonstrated the anti-inflammatory and antinociceptive activities of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dichotomaria obtusata/anti-inflammatory activity; Dichotomaria obtusata/analgesic activity; Mouse ear oedema test/Writhing test. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100014 |
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