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| Yan,Xi-Qing; Chen,Zhi-Gang; Wang,Rong-Liang; Yang,Jun; Ai,Fang; Pan,Yan-Juan; Qiu,Pei-Yong; Wang,Da-Xin. |
| The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not been reported, although it is very important to clinical use. In this paper, we investigated the PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules and the food influence in Chinese healthy volunteers. The PK parameters indicated that the diltiazem hydrochloride delay-onset sustained-release pellet capsules appeared marked characteristics of delayed and controlled release. An opened-label, randomized and parallel clinical trial was conducted in 36 Chinese healthy volunteers with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diltiazem hydrochloride/delay-onset sustained-release pellet capsules; Diltiazem hydrochloride/pharmacokinetics; Food/ingestion; Food/effect in pharmacokinetic profile; High-performance liquid chromatography/quantitative analysis. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100004 |
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