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Biochemical and biological properties of Lonomia obliqua bristle extract J. Venom. Anim. Toxins incl. Trop. Dis.
Chudzinski-Tavassi,A. M.; Carrijo-Carvalho,L. C..
Lonomia obliqua caterpillar is frequently seen in accidents with humans especially in the south of Brazil. Patients develop a hemorrhagic syndrome that can be treated with specific antilonomic serum. A consumptive coagulopathy was found to be the main cause of bleeding complications observed in patients after contact with L. obliqua. Studies revealed that L. obliqua caterpillar bristle extract (LOCBE) displays a procoagulant activity that leads to intravascular thrombin formation, resulting in a special form of disseminated intravascular coagulation (DIC). Fibrinolysis seems to be secondary to the fibrin production, since no direct fibrinolytic activity was found in LOCBE. Two procoagulant toxins, a factor X activator (Losac) and a prothrombin activator...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lonomia obliqua; Lonomia obliqua bristle extract; Hemorrhagic syndrome; Disseminated intravascular coagulation.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000200002
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Exogenous normal lymph alleviates microcirculation disturbances and abnormal hemorheological properties in rats with disseminated intravascular coagulation BJMBR
Niu,Chun-Yu; Zhao,Zi-Gang; Zhang,Yu-Ping; Hou,Ya-Li; Li,Jun-Jie; Jiang,Hua; Zhang,Jing.
Disturbances of the microcirculation and abnormal hemorheological properties are important factors that play an important role in disseminated intravascular coagulation (DIC) and result in organ dysfunction or failure. In the present study, we established an animal model of DIC using intravenous Dextran 500 in rats, and used exogenous normal lymph corresponding to 1/15 of whole blood volume for injection through the left jugular vein. We found that normal lymph could improve the blood pressure and survival time of rats with DIC. The results regarding the mesenteric microcirculation showed that the abnormality of the diameter of mesenteric microvessels and micro-blood flow speed in the DIC+lymph group was significantly less than in the DIC+saline group....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Disseminated intravascular coagulation; Lymph; Mesenteric microcirculation; Hemorheology; Dextran 500.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200138
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