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	Provedor de dados BJMBR (1) BJM (1) Autor Campos,Lívia Maria Soares (1) Henrique-Silva,F. (1) Oliveira,Lorena Vivien Neves (1) Ribeiro,Aurélia Silva (1) Santos,Daniel Assis (1) Santos,Gleicy Carla (1) Silva,Dágma Aparecida (1) Silva,Francislene Pereira (1) Silveira,H.C.S. (1) Soares-Costa,A. (1) Sommer,C.A. (1) Mais... Palavra-chave Down's syndrome (2) Calcineurin (1) Candida spp. (1) Cerebral palsy (1) Down's syndrome candidate region 1 (1) Metal retardation (1) Phospholipase (1) Protein interactions (1) Two-hybrid system (1) Ubiquitously expressed transcript (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2010 (1) 2004 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última A calcineurin inhibitory protein overexpressed in Down's syndrome interacts with the product of a ubiquitously expressed transcript BJMBR Silveira,H.C.S.; Sommer,C.A.; Soares-Costa,A.; Henrique-Silva,F.. The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. As an approach to clarifying a putative function for this protein, in the present study we used the yeast two-hybrid system to identify DSCR1 partners. The two-hybrid system is a method that allows the identification of protein-protein interactions through reconstitution of the activity of the yeast GAL 4 transcriptional activator. The gene DSCR1 fused to the GAL 4 binding domain (BD) was used to screen a human fetal brain cDNA library cloned in fusion with the GAL 4 activation domain (AD). Three positive clones were found and sequence analysis revealed that all the... Tipo: Info:eu-repo/semantics/other Palavras-chave: Down's syndrome; Down's syndrome candidate region 1; Calcineurin; Two-hybrid system; Ubiquitously expressed transcript; Protein interactions. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600002 Epidemiology and phospholipase activity of oral Candida spp. among patients with central nervous system diseases before and after dental cleaning procedure BJM Ribeiro,Aurélia Silva; Silva,Dágma Aparecida; Silva,Francislene Pereira; Santos,Gleicy Carla; Campos,Lívia Maria Soares; Oliveira,Lorena Vivien Neves; Santos,Daniel Assis. Patients suffering of diseases that affect central nervous system may be considered more susceptible to the infectious diseases of mouth. Sixty-nine patients suffering of cerebral palsy, Down's syndrome and metal retardation were submitted to saliva examination for the presence of Candida spp. before and after a procedure of dental cleaning. The isolates were submitted to assay for verifying phospholipase production. 55.10% of the patients provided isolation of Candida spp. The frequency of isolation obtained before dental procedure was: C. albicans (83.33%), C. krusei (8.33%) and C. kefyr, C. parapsilosis and C. glabrata (2.78% each). The frequency after the procedure was: C. albicans (68.57%), C. parapsilosis (11.43%), C. krusei and C. kefyr (8.57% each)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Candida spp.; Cerebral palsy; Down's syndrome; Metal retardation; Phospholipase. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000100004 Registros recuperados: 2 Primeira ... 1 ... Última

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