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	Provedor de dados BJM (1) BJPS (1) Autor Bottega,Angelita (1) Carvalho,Fernanda Aguirre (1) Demirelli,Meryem (1) Erdinc,Fatma Sebnem (1) Ertem,Gunay (1) Foletto,Vitória Segabinazzi (1) Hörner,Rosmari (1) Kinikli,Sami (1) Koksal,Eda (1) Rampelotto,Roberta Filipini (1) Rosa,Taciéli Fagundes da (1) Serafin,Marissa Bolson (1) Temocin,Fatih (1) Tulek,Necla (1) Mais... Palavra-chave Drug synergism (2) Acinetobacter (1) Antimicrobial drugs (1) Disulfiram.Antimicrobial activity (1) Drug repositioning (1) Drug resistance (1) Sertraline (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2015 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Synergistic effects of sulbactam in multi-drug-resistant Acinetobacter baumannii BJM Temocin,Fatih; Erdinc,Fatma Sebnem; Tulek,Necla; Demirelli,Meryem; Ertem,Gunay; Kinikli,Sami; Koksal,Eda. Abstract Acinetobacter baumannii is a frequently isolated etiologic agent of nosocomial infections, especially in intensive care units. With the increase in multi-drug resistance of A. baumannii isolates, finding appropriate treatment alternatives for infections caused by these bacteria has become more difficult, and available alternate treatments include the use of older antibiotics such as colistin or a combination of antibiotics. The current study aimed to evaluate the in vitro efficacy of various antibiotic combinations against multi-drug resistant A. baumannii strains. Thirty multi-drug and carbapenem resistant A. baumannii strains isolated at the Ankara Training and Research Hospital between June 2011 and June 2012 were used in the study. Antibiotic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Acinetobacter; Antimicrobial drugs; Drug resistance; Drug synergism. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000401119 Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning BJPS Serafin,Marissa Bolson; Bottega,Angelita; Foletto,Vitória Segabinazzi; Rosa,Taciéli Fagundes da; Rampelotto,Roberta Filipini; Carvalho,Fernanda Aguirre; Hörner,Rosmari. The repositioning of approved drugs is atopic of interest for the academy and the pharmaceutical industry. The synergistic combination of these drugs can be successful in the treatment of infections caused by resistant bacteria. This study aimed to assess the in vitro synergistic antibacterial activity of sertraline and disulfiram and their interaction with ciprofloxacin and sulfamethoxazole/trimethoprim. We determined the minimum inhibitory concentration, the minimum bactericidal concentration and the fractional inhibitory concentration index. Eighteen bacterial strains were used, being nine American Type Culture Collection reference strains and nine multidrug resistant clinical isolates. Synergy was detected between sertraline and disulfiram against a... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sertraline; Disulfiram.Antimicrobial activity; Drug synergism; Drug repositioning. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100548 Registros recuperados: 2 Primeira ... 1 ... Última

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