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	Provedor de dados BJPS (1) Autor Daravath,Bhaskar (1) Naveen,Chella (1) Tadikonda,Rama Rao (1) Vemula,Sateesh Kumar (1) Palavra-chave Dissolution efficiency (1) Drug-carrier compatibility/study (1) Flurbiprofen/dissolution rate (1) Flurbiprofen/solubility (1) Polyethylene glycol/effects (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Solubility and dissolution enhancement of flurbiprofen by solid dispersion using hydrophilic carriers BJPS Daravath,Bhaskar; Naveen,Chella; Vemula,Sateesh Kumar; Tadikonda,Rama Rao. ABSTRACT The intent of the current work is to study the effect of polyethylene glycol 8000 and polyethylene glycol 10000 as hydrophilic carriers on dissolution behaviour of flurbiprofen. In the present study, solvent evaporation method was used to prepare flurbiprofen solid dispersions and evaluated for physico-chemical properties, drug-carrier compatibility studies and dissolution behaviour of drug. Solubility studies showed more solubility in higher pH values and formulations SD4 and SD8 were selected to prepare the fast dissolving tablets. FTIR and DSC study showed no interaction and drug was dispersed molecularly in hydrophilic carrier. XRD studies revealed that there was change in the crystallinity of the drug. The results of In vitro studies showed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Polyethylene glycol/effects; Flurbiprofen/solubility; Flurbiprofen/dissolution rate; Drug-carrier compatibility/study; Dissolution efficiency. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400625 Registros recuperados: 1 Primeira ... 1 ... Última

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