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	Provedor de dados 60 (3) Autor Ansari,Khalid Akhter (1) Anwar,Shoeb (1) Balaji,Sakamuri (1) Bazzo,Giovana Carolina (1) Crenca,Janine Paula (1) Macedo,Aline Teixeira de (1) Murthy,Kolapalli Venkata Ramana (1) Pagar,Kunal Pratap (1) Pereira,Eduardo Manoel (1) Pezzini,Bianca Ramos (1) Rao,Nali Sreenivasa (1) Silva,Virgínia Emiliana (1) Srikanth,Meka Venkata (1) Sunil,Songa Ambedkar (1) Vavia,Pradeep Ratilal (1) Zétola,Melissa (1) Mais... Palavra-chave Drugs/controlled release (3) Bilayered tablet/biphasic release (1) Chronotherapeutics/hypertension treatment (1) Drugs/in vitro study (1) Drugs/in vivo evaluation (1) Ethyl cellulose/drugs coated (1) Felodipine/chronotherapeutic application (1) Felodipine/self-microemulsifying delivery (1) Hydrophilic polymers/drug release (1) Hydrophilic polymers/use (1) Hypertension/treatment (1) Ibuprofen/release (1) Lornoxicam/bilayered tablet (1) Lornoxicam/development (1) Microspheres/preparation (1) Poly(hydroxybutyrate-co-hydroxyvalerate) (1) Poly(l-lactide) (1) Self-microemulsifying drug delivery system/development (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2014 (1) 2012 (2) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Design and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application 60 Ansari,Khalid Akhter; Pagar,Kunal Pratap; Anwar,Shoeb; Vavia,Pradeep Ratilal. The objective of this research work was to design, develop and optimize the self micro-emulsifying drug delivery system (SMEDDS) of Felodipine (FL) filled in hard gelatine capsule coated with polymer in order to achieve rapid drug release after a desired time lag in the management of hypertension. Microemulsion is composed of a FL, Lauroglycol FCC, Transcutol P and Cremophor EL. The optimum surfactant to co-surfactant ratio was found to be 2:1. The resultant microemulsions have a particle size in the range of 65-85 nm and zeta potential value of -13.71 mV. FL release was adequately adjusted by using pH independent polymer i.e. ethyl cellulose along with dibutyl phthalate as plasticizer. Influence of formulation variables like viscosity of polymer, type of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Felodipine/self-microemulsifying delivery; Felodipine/chronotherapeutic application; Self-microemulsifying drug delivery system/development; Drugs/controlled release; Ethyl cellulose/drugs coated; Hypertension/treatment; Chronotherapeutics/hypertension treatment. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100021 Microspheres prepared with biodegradable PHBV and PLA polymers as prolonged-release system for ibuprofen: in vitro drug release and in vivo evaluation 60 Bazzo,Giovana Carolina; Macedo,Aline Teixeira de; Crenca,Janine Paula; Silva,Virgínia Emiliana; Pereira,Eduardo Manoel; Zétola,Melissa; Pezzini,Bianca Ramos. In this study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and poly(l-lactide) (PLA) microspheres containing ibuprofen were prepared with the aim of prolonging the drug release. The oil-in-water (O/W) emulsion solvent evaporation technique was used, varying the polymer ratio. All formulations provided spherical particles with drug crystals on the surface and a porous and rough polymeric matrix when PHBV was used and smooth external surface when prepared with PLA. The in vitro dissolution profiles show that the formulation containing PHBV/PLA at the proportion of 30/70 presented the best results in terms of prolonging the ibuprofen release. The analysis of the concentration of ibuprofen in the blood of rats showed that maximum levels were achieved at... Tipo: Info:eu-repo/semantics/article Palavras-chave: Microspheres/preparation; Poly(hydroxybutyrate-co-hydroxyvalerate); Poly(l-lactide); Ibuprofen/release; Drugs/controlled release; Drugs/in vitro study; Drugs/controlled release; Drugs/in vivo evaluation. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400021 Design and evaluation of lornoxicam bilayered tablets for biphasic release 60 Sunil,Songa Ambedkar; Srikanth,Meka Venkata; Rao,Nali Sreenivasa; Balaji,Sakamuri; Murthy,Kolapalli Venkata Ramana. The objective of the present investigation was to develop bilayered tablets of lornoxicam to achieve biphasic release pattern. A bilayered tablet, consisting of an immediate and controlled release layer, was prepared by direct compression technique. The controlled release effect was achieved by using various hydrophilic natural, semi synthetic and synthetic controlled release polymers such as xanthan gum, hydroxypropyl methylcellulose (HPMC) and polyethylene oxide (PEO) to modulate the release of the drug. The in vitro drug release profiles showed the biphasic release behavior in which the immediate release (IR) layer containing the lornoxicam was released within 15 minutes, whereas the controlled release (CR) layer controlled the drug release for up to 24... Tipo: Info:eu-repo/semantics/article Palavras-chave: Lornoxicam/bilayered tablet; Lornoxicam/development; Bilayered tablet/biphasic release; Hydrophilic polymers/use; Hydrophilic polymers/drug release; Drugs/controlled release. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400004 Registros recuperados: 3 Primeira ... 1 ... Última

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