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Conus vexillum venom induces oxidative stress in Ehrlich's ascites carcinoma cells: an insight into the mechanism of induction J. Venom. Anim. Toxins incl. Trop. Dis.
Abdel-Rahman,Mohamed A; Abdel-Nabi,Ismail M; El-Naggar,Mohamed S; Abbas,Osama A; Strong,Peter N.
Background It is estimated that venoms of marine cone snails (genus Conus) contain more than 100,000 different small peptides with a wide range of pharmacological and biological actions. Some of these peptides were developed into potential therapeutic agents and as molecular tools to understand biological functions of nervous and cardiovascular systems. In this study we examined the cytotoxic and anticancer properties of the marine vermivorous cone snail Conus vexillum (collected from Hurgada and Sharm El-Shaikh, Red Sea, Egypt) and suggest the possible mechanisms involved. The in vitro cytotoxic effects of Conus venom were assessed against Ehrlich’s ascites carcinoma (EAC) cells. Results Conus venom treatment resulted in concentration-dependent...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Conus vexillum venom; Ehrlich’s cells; Oxidative stress; Cancer; Egypt.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100307
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