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| Smith,M.A.C.; Silva,M.D.A.; Cendoroglo,M.S.; Ramos,L.R.; Araujo,L.M.Q.; Labio,R.W.; Burbano,R.R.; Chen,E.S.; Payão,S.L.M.. |
| TP53, a tumor suppressor gene, has a critical role in cell cycle, apoptosis and cell senescence and participates in many crucial physiological and pathological processes. Identification of TP53 polymorphism in older people and age-related diseases may provide an understanding of its physiology and pathophysiological role as well as risk factors for complex diseases. TP53 codon 72 (TP53:72) polymorphism was investigated in 383 individuals aged 66 to 97 years in a cohort from a Brazilian Elderly Longitudinal Study. We investigated allele frequency, genotype distribution and allele association with morbidities such as cardiovascular disease, type II diabetes, obesity, neoplasia, low cognitive level (dementia), and depression. We also determined the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cardiovascular risk factors; HDL; Lipid metabolism; TP53 polymorphism codon 72; Age-related diseases; Elderly cohort. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100007 |
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