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| Luo,Fo-Quan; Liu,Jun-Wu; Tang,Shu-Xin; Zhao,Wei-Lu; Hu,Yan; Xu,Lin; Li,Meng-Yuan. |
| This work aims to study the pathogenesis of learning and memory impairment in offspring rats resulting from maternal enflurane anesthesia by focusing on the expression of the N-methyl-d-aspartic acid receptor subunit 2B (NR2B) in the hippocampus of the offspring. Thirty female Sprague-Dawley rats were randomly divided into three groups: control (C group), 4 h enflurane exposure (E1 group), and 8 h enflurane exposure (E2 group) groups. Eight to ten days after the initiation of pregnancy, rats from the E1 and E2 groups were allowed to inhale 1.7% enflurane in 2 L/min oxygen for 4 h and 8 h, respectively. Rats from the C group were allowed to inhale 2 L/min of oxygen only. The Morris water maze was used to assay the learning and memory function of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Enflurane/use/maternal anesthesia; Enflurane/adverse effects/experimental study; Enflurane/effects/pregnancy; N-methyl-D-aspartic acid/receptor/gene expression. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300673 |
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