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Estrogen replacement therapy and cardioprotection: mechanisms and controversies BJMBR
Subbiah,M.T.R..
Epidemiological and case-controlled studies suggest that estrogen replacement therapy might be beneficial in terms of primary prevention of coronary heart disease (CHD). This beneficial effect of estrogens was initially considered to be due to the reduction of low density lipoproteins (LDL) and to increases in high density lipoproteins (HDL). Recent studies have shown that estrogens protect against oxidative stress and decrease LDL oxidation. Estrogens have direct effects on the arterial tissue and modulate vascular reactivity through nitric oxide and prostaglandin synthesis. While many of the effects of estrogen on vascular tissue are believed to be mediated by estrogen receptors alpha and ß, there is evidence for `immediate non-genomic' effects. The role...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Estrogen therapy; Postmenopausal women; Cardiovascular disease; Plasma lipoproteins; Lipoprotein oxidation; Estrogen receptors; Thrombosis; Nitric oxide synthesis.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300001
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Autonomic modulation of heart rate of young and postmenopausal women undergoing estrogen therapy BJMBR
Neves,V.F.C.; Silva de Sá,M.F.; Gallo Jr.,L.; Catai,A.M.; Martins,L.E.B.; Crescêncio,J.C.; Perpétuo,N.M.; Silva,E..
The aim of the present study was to determine whether estrogen therapy (ET) reduces alterations of the autonomic control of heart rate (HR) due to hypoestrogenism and aging. Thirteen young (24 ± 2.6 years), 10 postmenopausal (53 ± 4.6 years) undergoing ET (PM-ET), and 14 postmenopausal (56 ± 2.6 years) women not undergoing ET (PM) were studied. ET consisted of 0.625 mg/day conjugated equine estrogen. HR was recorded continuously for 8 min at rest in the supine and sitting positions. HR variability (HRV) was analyzed by time (SDNN and rMSSD indices) and frequency domain methods. Power spectral components are reported as normalized units (nu) at low (LF) and high (HF) frequencies, and as LF/HF ratio. Intergroup comparisons: SDNN index was higher in young...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart rate variability; Aging; Menopause; Estrogen therapy.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400007
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