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	Provedor de dados BJPS (2) Autor Amin,Jinal (1) Paradkar,Mansi (1) Rai,Awanik (1) Srivastava,Birendra (1) Tiwari,Gaurav (1) Tiwari,Ruchi (1) Mais... Palavra-chave Eudragit S100 (2) Acrylic polymers (1) Drugs/extended release (1) Ethyl cellulose (1) Eudragit RL100 (1) Ex-vivo drug release study (1) Extended realease/pharmacotechnics (1) Extrusion-spheronization (1) Freeze drying/pharmacotechnics (1) Microcrystalline cellulose (1) Modified fluid bed coater (1) Pharmaceutical formulations/evaluation (1) Promethazine hydrochloride/extended release (1) Spray drying/pharmacotechnics (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Formulation development and evaluation of colon targeted delayed release methotrexate pellets for the treatment of colonic carcinoma BJPS Paradkar,Mansi; Amin,Jinal. Colonic carcinoma is one of the most common internal malignancies and is the second leading cause of deaths in United States. Methotrexate (MTX) is a drug of choice in the treatment of colon cancer. The aim of the present research work was to develop and characterize colon targeted pellets of MTX for treatment of colonic carcinoma. The product and process parameters were optimized by screening methods. Pellets were prepared by extrusion spheronization using microcrystalline cellulose (MCC) as spheronizing aid and ethyl cellulose (EC) as release retardant in different ratio. Based on the physical appearance, sphericity and % in vitro drug release, batch P17 containing EC: MCC (3:7) was optimized for core pellets. The site specificity was obtained by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ethyl cellulose; Microcrystalline cellulose; Eudragit S100; Extrusion-spheronization; Modified fluid bed coater; Ex-vivo drug release study. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400608 Extended release promethazine HCl using acrylic polymers by freeze-drying and spray-drying techniques: formulation considerations BJPS Tiwari,Ruchi; Srivastava,Birendra; Tiwari,Gaurav; Rai,Awanik. The present study investigated a novel extended release system of promethazine hydrochloride (PHC) with acrylic polymers Eudragit RL100 and Eudragit S100 in different weight ratios (1:1 and 1: 5), and in combination (0.5+1.5), using freeze-drying and spray-drying techniques. Solid dispersions were characterized by Fourier-transformed infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), Nuclear magnetic resonance (NMR), Scanning electron microscopy (SEM), as well as solubility and in vitro dissolution studies in 0.1 N HCl (pH 1.2), double-distilled water and phosphate buffer (pH 7.4). Adsorption tests from drug solution to solid polymers were also performed. A selected solid dispersion system was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Promethazine hydrochloride/extended release; Drugs/extended release; Eudragit RL100; Eudragit S100; Acrylic polymers; Spray drying/pharmacotechnics; Freeze drying/pharmacotechnics; Extended realease/pharmacotechnics; Pharmaceutical formulations/evaluation. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400029 Registros recuperados: 2 Primeira ... 1 ... Última

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