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	Provedor de dados Anais da ABC (AABC) (1) Autor Monteiro,Robson Q. (1) Palavra-chave Blood coagulation (1) Exogenous inhibitors (1) Exosites (1) Serine proteases (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2005 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Targeting exosites on blood coagulation proteases Anais da ABC (AABC) Monteiro,Robson Q.. The high specificity of blood coagulation proteases has been attributed not only to residues surrounding the active site but also to other surface domains that are involved in recognizing and interacting with macromolecular substrates and inhibitors. Specific blood coagulation inhibitors obtained from exogenous sources such as blood sucking salivary glands and snake venoms have been identified. Some of these inhibitors interact with exosites on coagulation enzymes. Two examples are discussed in this short revision. Bothrojaracin is a snake venom-derived protein that binds to thrombin exosites 1 and 2. Complex formation impairs several exosite-dependent activities of thrombin including fibrinogen cleavage and platelet activation. Bothrojaracin also... Tipo: Info:eu-repo/semantics/article Palavras-chave: Blood coagulation; Serine proteases; Exosites; Exogenous inhibitors. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000200007 Registros recuperados: 1 Primeira ... 1 ... Última

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