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| Marques,K.B.; Scorisa,J.M.; Zanon,R.; Freria,C.M.; Santos,L.M.B.; Damasceno,B.P.; Oliveira,A.L.R.. |
| The immunomodulador glatiramer acetate (GA) has been shown to significantly reduce the severity of symptoms during the course of multiple sclerosis and in its animal model - experimental autoimmune encephalomyelitis (EAE). Since GA may influence the response of non-neuronal cells in the spinal cord, it is possible that, to some extent, this drug affects the synaptic changes induced during the exacerbation of EAE. In the present study, we investigated whether GA has a positive influence on the loss of inputs to the motoneurons during the course of EAE in rats. Lewis rats were subjected to EAE associated with GA or placebo treatment. The animals were sacrificed after 15 days of treatment and the spinal cords processed for immunohistochemical analysis and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Experimental autoimmune encephalomyelitis; Spinal cord; Synapse elimination; Motoneuron; Immunomodulator; Glatiramer acetate. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200006 |
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| Zeng,Y.; Song,C.; Ding,X.; Ji,X.; Yi,L.; Zhu,K.. |
| Scutellaria baicalensis Georgi is one of the important medicinal herbs widely used for the treatment of various inflammatory diseases in Asia. Baicalin (BA) is a bioactive anti-inflammatory flavone found abundantly in Scutellaria baicalensis Georgi. To explore the therapeutic potential of BA, we examined the effects of systemic administration of the flavone (5 and 10 mg/kg, ip) on relapsing/remitting experimental autoimmune encephalomyelitis (EAE) induced by proteolipid protein 139-151 in SJL/J mice, an experimental model of multiple sclerosis. The mice treated with PBS or BA at day -1 and for 3 consecutive days were observed daily for clinical signs of disease up to 60 days after immunization. In the PBS-EAE group, neurological scores were: incidence... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Experimental autoimmune encephalomyelitis; Baicalin; IFN-g; IL-4; Neurologic score. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700016 |
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