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	Provedor de dados BJMBR (19) Rev. Microbiol. (6) Rev. Bras. Bot. (2) R. Bras. Zootec. (2) BJM (1) Scientia Agricola (1) Rev. bras. sementes (1) Mais... Autor Bahia-Oliveira,L.M.G. (2) Coffman,R.L. (2) Corrêa-Oliveira,R. (2) Eler,Joanir Pereira (2) Ferraz,José Bento Sterman (2) Gazzinelli,G. (2) Silva,Josineudson Augusto II de Vasconcelos (2) Aarestrup,F.M. (1) Abreu-e-Silva,F.A. (1) Aliberti,J.C.S. (1) Almeida,Leila P. (1) Alves,Thelma (1) Azevedo,Ana C. (1) BARBOSA,EDELCILIO (1) Bacellar,O. (1) Balatti,Antonio (1) Barros,S.B.M. (1) Belote,Juliana Gisele (1) Bernoux,Martial (1) Bertho,A.L. (1) Mais... Palavra-chave FONT FACE=Symbol> (32) /font> (20) A< (16) /FONT> (12) G< (7) < (4) B< (3) D< (3) Â< (2) -1 3-glucanase proteinase inhibitors defense proteins (1) -Galactosidase galactosyltransferase galactooligosaccharides lactose prebiotic effect (1) -MSH AV3V ANP natriuresis kaliuresis diuresis (1) -MSH synthetic analogue minigrafting (1) -adrenergic receptors prostaglandin E2 arginine citrulline NMMA sodium nitroprusside (1) -amilase amido açúcares proteínas alterações bioquímicas sal (1) -amino N-ureide N-amide Bradyrhizobium (Lupinus) nodule cytosol (1) -amylase Aspergillus tamarii glucoamylase (1) -amylase acid cheese whey automatic pH control (1) -blockers vagotomy (1) -hydroxyalkanoate PHA resistance to antibiotics sugarcane agroecosystem vinasse (1) Mais... Tipo do documento Info:eu-repo/semantics/article (24) Info:eu-repo/semantics/other (8) Ano 2008 (1) 2006 (1) 2003 (2) 1999 (10) 1998 (12) 1997 (6) Mais... País Brazil (32) Idioma Inglês (28) Português (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 32 Primeira ... 1 2 ... Última Insecticidal and antifungic proteins of the latex from Manihot glaziovii Muell. Arg. Rev. Bras. Bot. PEREIRA,LUCILENE S.; GOMES,VALDIRENE M.; FERNANDES,KÁTIA V. S.; SALES,MAURÍCIO P.; XAVIER-FILHO,JOSÉ. Analysis of the latex from Manihot glaziovii showed the presence of various enzymatic and inhibitory activities. The latex also presented an inhibitory effect on the development of cowpea weevil (Callosobruchus maculatus) in an artificial seed system and on the development, in an in vitro assay, of phytopathogenic fungi Colletotrichum gloesporioides, Fusarium solani and Macrophomina phaseolina. These results suggest the presence of substances, some of them of protein nature, involved in plant defense mechanisms in this exudation product. Tipo: Info:eu-repo/semantics/article Palavras-chave: Latex chitinase <; FONT FACE=Symbol>; B<; /FONT>; -1 3-glucanase proteinase inhibitors defense proteins. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84041999000100005 Natural abundance of 13C in tropical grasses from the INPA, Instituto Nacional de Pesquisas da Amazônia, herbarium Rev. Bras. Bot. MEDINA,ERNESTO; MARTINELLI,LUIZ ANTONIO; BARBOSA,EDELCILIO; VICTORIA,REYNALDO LUIZ. The stable carbon isotopic composition of 165 grass species was determined with the objective of verifying their photosynthetic pathway (C3 and C4). The samples, taken from the INPA herbarium, were mainly collected in the North of Brazil. Approximately 60% of the species proved to be of the C4 type, with <FONT FACE="Symbol">d</font> 13C values ranging from -13.6 to -9.5‰, while the remainder 40% belonged to the C3 type, with values ranging from -34.7 to -23.4‰. This relatively high proportion of C3 species is probably due to the high relative humidity of the sites where the species were collected. Tipo: Info:eu-repo/semantics/article Palavras-chave: Grasses Amazon <; FONT FACE=Symbol>; D<; /font>; 13C photosynthetic cycle C3 C4. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84041999000100007 Composição química de sementes de trigo (Triticum aestivum L.) submetidas a estresse salino na germinação Rev. bras. sementes Silva,Rodrigo Nascimento da; Duarte,Gisela Loureiro; Lopes,Nei Fernandes; Moraes,Dario Munt de; Pereira,Ana Lúcia de Almeida. O objetivo do experimento foi determinar algumas alterações bioquímicas de sementes de duas cultivares de trigo (BRS 177 e BRS 179) sob influência de diferentes níveis de sal (zero, 15, 30, 45 e 60mM NaCl) no processo de germinação. O ensaio foi realizado para avaliar alterações na atividade da a-amilase e nos teores de amido, açúcares redutores, carboidratos solúveis totais e proteínas causadas pelo estresse salino. A atividade da a-amilase e os teores carboidratos solúveis totais, açúcares redutores e proteínas são reduzidos, porém o conteúdo de amido aumenta com o incremento da salinidade, em ambas cultivares de trigo. Em todas as concentrações de NaCl, os componentes químicos nas sementes da cultivar BRS 179 são maiores do que os da cv. BRS 177,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Triticum aestivum L. <; FONT FACE=Symbol>; A<; /font>; -amilase amido açúcares proteínas alterações bioquímicas sal. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-31222008000100027 Estimação de parâmetros genéticos em bovinos de corte utilizando os métodos de máxima verossimilhança restrita e  R. Bras. Zootec. Melis,Marcelo Hessel Van; Eler,Joanir Pereira; Silva,Josineudson Augusto II de Vasconcelos; Ferraz,José Bento Sterman. Com o objetivo de comparar as estimativas de parâmetros genéticos obtidas pelos métodos de máxima verossimilhança restrita (REML) e <FONT FACE=Symbol>Â</FONT>, foram realizadas análises uni-características sob modelo animal, para os quais foi utilizado um conjunto de dados da raça Nelore. Os modelos estatísticos incluíram os efeitos fixos de grupo de contemporâneos (fazenda, ano de nascimento, sexo e grupos de manejo à desmama e ao sobreano) e idade do animal (covariável linear), e como aleatórios foram considerados os efeitos genético aditivo direto e residual. As estimativas dos coeficientes de herdabilidade foram 0,36 e 0,39 para peso aos 18 meses (PESSOB); 0,27 e 0,29 para ganho de peso da desmama aos 18 meses (GP345); 0,22 e 0,21 para... Tipo: Info:eu-repo/semantics/article Palavras-chave: Características de crescimento escore visual Método <; FONT FACE=Symbol>; Â<; /FONT>; Nelore parâmetros genéticos REML. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982003000700011 Estimação de parâmetros genéticos para probabilidade de prenhez aos 14 meses e altura na garupa em bovinos da raça Nelore R. Bras. Zootec. Silva,Josineudson Augusto II de Vasconcelos; Van Melis,Marcelo Hessel; Eler,Joanir Pereira; Ferraz,José Bento Sterman. Registros de 24.703 animais da raça Nelore, provenientes de seis fazendas, foram utilizados para estimar os coeficientes de herdabilidade e a correlação genética relativos às características probabilidade de prenhez aos 14 meses (PP14) e altura na garupa aos 450 dias de idade (AG450). O modelo matemático incluiu os efeitos fixos de grupo de contemporâneo (181 grupos) e classe de idade da mãe ao parto (7 classes) para PP14 e o efeito fixo de grupo de contemporâneo (584 grupos) para AG450. Os efeitos aleatórios incluídos em ambos os modelos foram genético aditivo do touro e residual. Os componentes de variância e covariância foram obtidos pelo método <FONT FACE=Symbol>Â</FONT>. As estimativas de herdabilidade foram iguais a 0,73 ± 0,01 e 0,30 ±... Tipo: Info:eu-repo/semantics/article Palavras-chave: Altura na garupa correlação genética herdabilidade método <; FONT FACE=Symbol>; Â<; /FONT>; Prenhez de novilha. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982003000500014 Nitrate levels and stages of growth in hypernodulating mutants of Lupinus albus. II. Enzymatic activity and transport of N in the xylem sap Rev. Microbiol. Burity,Hélio Almeida; Chamber-Perez,Manuel; Lyra,Maria do Carmo Catanho Pereira de; Figueiredo,Márcia do Vale Barreto. The enzymatic study and transport of N in the xylem sap was carried out with a view to observing the influence of different nitrate levels and growth stages of the plant in chemically treated mutants of Lupinus albus. Several stresses induce a reduction in plant growth, resulting in the accumulation of free amino acids, amides or ureides, not only in the shoot, but also in the roots and nodules. Although enzyme activity is decisive in avoiding products that inhibit nitrogenase by ammonium, little is known about the mechanism by which the xylem carries these products. However, this process may be the key to the function of avoiding the accumulation of amino acids in the cells of infected nodules. The behaviour of the enzymes nitrate reductase (NR),... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitrate reductase phosphoenolpyruvate carboxylase glutamine synthetase N-<; FONT FACE=Symbol>; A<; /font>; -amino N-ureide N-amide Bradyrhizobium (Lupinus) nodule cytosol. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141999000200002 Bacteria isolated from a sugarcane agroecosystem: their potential production of polyhydroxyalcanoates and resistance to antibiotics Rev. Microbiol. Lima,Teresa Cristina S. de; Grisi,Breno M.; Bonato,M. Christina M.. In this investigation, a sugarcane agroecosystem at a coastal tableland, in the northeast of Brazil, was screened to obtain bacteria strains able to synthesize poly-<FONT FACE="Symbol">b</font>-hydroxyalkanoates (PHA), using sucrose as the main carbon source. The potential to synthesize PHA was tested qualitatively by Sudan Black staining of colonies growing in different carbon sources: sucrose, glucose, fructose, propionate and cellulose. In a typical sugarcane crop management system, the plantation is burned before harvesting and vinasse, a byproduct of alcohol production, is used in a fertirrigation system causing, probably, selective pressures on the microbiota of natural environments. Eightytwo bacteria strains, belonging to 16 different... Tipo: Info:eu-repo/semantics/article Palavras-chave: Soil bacteria poly-<; FONT FACE=Symbol>; B<; /font>; -hydroxyalkanoate PHA resistance to antibiotics sugarcane agroecosystem vinasse. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141999000300006 Production of amylases by Aspergillus tamarii Rev. Microbiol. Moreira,Fabiana Guillen; Lima,Francieli Arrias de; Pedrinho,Sophia Renata Fazzano; Lenartovicz,Veridiana; Souza,Cristina Giatti Marques de; Peralta,Rosane Marina. A strain of Aspergillus tamarii, a filamentous fungus isolated from soil, was able to produce both <FONT FACE="Symbol">a</FONT>-amylase and glucoamylase activities in mineral media supplemented with 1% (w/v) starch or maltose as the carbon source. Static cultivation led to significantly higher yields than those obtained using shaking culture. The production of amylases was tolerant to a wide range of initial culture pH values (from 4 to 10) and temperature (from 25 to 42oC). Two amylases, one <FONT FACE="Symbol">a</FONT>-amylase and one glucoamylase, were separated by ion exchange chromatography. Both partially purified enzymes had optimal activities at pH values between 4.5 and 6.0 and were stable under acid conditions (pH... Tipo: Info:eu-repo/semantics/article Palavras-chave: <; FONT FACE=Symbol>; A<; /FONT>; -amylase Aspergillus tamarii glucoamylase. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141999000200014 Production of a-amylase in acid cheese whey culture media with automatic pH control Rev. Microbiol. Ferreyra,Rosana; Lorda,Graciela; Balatti,Antonio. The influence of aeration and automatic pH control on the production of <FONT FACE="Symbol">a</FONT>-amylase by a strain of Bacillus subtilis NRRL 3411 from acid cheese whey was studied. Tests were carried out in a rotary shaker and in mechanically stirred fermenters. <FONT FACE="Symbol">a</FONT>-amylase was analysed according to DUN’s method. Oxygen absorption rate was determined by Cooper’s method. Cell oxygen demand was determined as oxygen consumption in a Warburg respirometer. The level of dissolved oxygen was measured by means of a galvanic silver-lead electrode. Results suggest the possibility of industrial use of acid cheese whey as a carbon source for <FONT FACE="Symbol">a</FONT>-amylase production, since the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bacillus subtilis <; FONT FACE=Symbol>; A<; /FONT>; -amylase acid cheese whey automatic pH control. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000400005 INTERFERON SELECTIVELY INHIBITS THE SYNTHESIS OF MAYARO VIRUS GLYCOPROTEINS Rev. Microbiol. Ferreira,Davis F.; Rebello,Maria Christina Soares. We have previously observed that interferon (recIFN<FONT FACE="Symbol">a</FONT>2b) blocks the process of morphogenesis of Mayaro virus in TC7 cells (monkey kidney). In this work we show that IFNa inhibits preferentially virus glycoproteins and their precursors, and this effect is probably correlated to the alterations in the morphogenesis process previously observed. Tipo: Info:eu-repo/semantics/other Palavras-chave: Interferon <; FONT FACE=Symbol>; A<; /FONT>; Mayaro virus glycoproteins morphogenesis. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000300014 Properties of a new fungal b-galactosidase with potential application in the dairy industry Rev. Microbiol. Cruz,Rubens; Cruz,Vinícius D'Arcádia; Belote,Juliana Gisele; Khenayfes,Marcelo de Oliveira; Dorta,Claudia; Oliveira,Luiza Helena dos Santos. <FONT FACE="Symbol">b</font>-Galactosidase or <FONT FACE="Symbol">b</font>-D-galactoside-galactohydrolase (EC. 3.2.1.23) is an important enzyme industrially used for the hydrolysis of lactose from milk and milk whey for several applications. Lately, the importance of this enzyme was enhanced by its galactosyltransferase activity, which is responsible for the synthesis of transgalactosylated oligosaccharides (TOS) that act as functional foods, with several beneficial effects on consumers. Penicillium simplicissimum, a strain isolated from soil, when grown in semi-solid medium showed good productivity of <FONT FACE="Symbol">b</font>-galactosidase with galactosyltransferase activity. The optimum pH for hydrolysis was in the... Tipo: Info:eu-repo/semantics/article Palavras-chave: <; FONT FACE=Symbol>; B<; /font>; -Galactosidase galactosyltransferase galactooligosaccharides lactose prebiotic effect. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141999000300014 Carbono e nitrogênio em solo de uma cronossequência de floresta tropical - pastagem de Paragominas Scientia Agricola Bernoux,Martial; Feigl,Brigitte Josefine; Cerri,Carlos Clemente; Geraldes,Ana Paula de Arauda; Fernandes,Silvana Aparecida Pavan. Amostras de terra de áreas desmatadas há 4, 10 e 15 anos e utilizadas como pastagem e uma floresta nativa na região de Paragominas-PA, foram analisadas quanto à constituição isotópica e teor de carbono (C) e nitrogênio (N) com o objetivo de quantificar os estoques de C e N e as alterações devidas a mudanças do uso da terra. O conteúdo de C e N aumentaram ao longo do tempo de uso do solo como pastagem. Após 4 e 15 anos de cultivo o conteúdo de C aumentou 0,28 e 0,86 kg.m-2 na camada superficial 0-30 cm do solo; a pastagem de 10 anos ficou estável (diminuição de 0,02 kg.m-2) em relação à mata natural para a camada 0-30 cm, mas diminuiu de 0,15 na camada 0-10 cm. Na camada superficial 0-30 cm, a matéria orgânica da área sob mata natural é composta por 2,6... Tipo: Info:eu-repo/semantics/article Palavras-chave: Matéria orgânica pastagem floresta Amazônica <; FONT FACE=Symbol>; D<; /font>; 13C carbono nitrogênio. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90161999000400003 Pituitary glycoprotein hormone a-subunit secretion by cirrhotic patients BJMBR Oliveira,M.C.; Pizarro,C.B.; Cassal,A.; Cremonese,R.; Vieira,J.G.H.. Secretion of the <FONT FACE="Symbol">a</font>-subunit of pituitary glycoprotein hormones usually follows the secretion of intact gonadotropins and is increased in gonadal failure and decreased in isolated gonadotropin deficiency. The aim of the present study was to determine the levels of the <FONT FACE="Symbol">a</font>-subunit in the serum of patients with cirrhosis of the liver and to compare the results obtained for eugonadal cirrhotic patients with those obtained for cirrhotic patients with hypogonadotropic hypogonadism. Forty-seven of 63 patients with cirrhosis (74.6%) presented hypogonadism (which was central in 45 cases and primary in 2), 7 were eugonadal, and 9 women were in normal menopause. The serum <FONT... Tipo: Info:eu-repo/semantics/article Palavras-chave: <; FONT FACE=Symbol>; A<; /font>; -subunit pituitary gonadotropins hypogonadism cirrhosis. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000100011 Antioxidant activity of the microalga Spirulina maxima BJMBR Miranda,M.S.; Cintra,R.G.; Barros,S.B.M.; Mancini-Filho,J.. Spirulina maxima, which is used as a food additive, is a microalga rich in protein and other essential nutrients. Spirulina contains phenolic acids, tocopherols and ß-carotene which are known to exhibit antioxidant properties. The aim of the present study was to evaluate the antioxidant capacity of a Spirulina extract. The antioxidant activity of a methanolic extract of Spirulina was determined in vitro and in vivo. The in vitro antioxidant capacity was tested on a brain homogenate incubated with and without the extract at 37oC. The IC50 (concentration which causes a 50% reduction of oxidation) of the extract in this system was 0.18 mg/ml. The in vivo antioxidant capacity was evaluated in plasma and liver of animals receiving a daily dose of 5 mg for 2 and... Tipo: Info:eu-repo/semantics/other Palavras-chave: Microalgae antioxidant activity Spirulina maxima phenolic compounds ß-carotene <; FONT FACE=Symbol>; A<; /FONT>; -tocopherol. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000800007 Optimized Fast-FISH with a-satellite probes: acceleration by microwave activation BJMBR It has been shown for several DNA probes that the recently introduced Fast-FISH (fluorescence in situ hybridization) technique is well suited for quantitative microscopy. For highly repetitive DNA probes the hybridization (renaturation) time and the number of subsequent washing steps were reduced considerably by omitting denaturing chemical agents (e.g., formamide). The appropriate hybridization temperature and time allow a clear discrimination between major and minor binding sites by quantitative fluorescence microscopy. The well-defined physical conditions for hybridization permit automatization of the procedure, e.g., by a programmable thermal cycler. Here, we present optimized conditions for a commercially available X-specific <FONT... Tipo: Info:eu-repo/semantics/other Palavras-chave: Fluorescence in situ hybridization Fast-FISH metaphase chromosomes <; FONT FACE=Symbol>; A<; /font>; -satellite DNA probes microwave treatment quantitative image analysis. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000100003 The role of IL-12 in experimental Trypanosoma cruzi infection BJMBR Silva,J.S.; Aliberti,J.C.S.; Martins,G.A.; Souza,M.A.; Souto,J.T.; Pádua,M.A.. Host resistance to Trypanosoma cruzi infection is dependent on both natural and acquired immune responses. During the early acute phase of infection in mice, natural killer (NK) cell-derived IFN-<FONT FACE="Symbol">g</font> is involved in controlling intracellular parasite replication, mainly through the induction of nitric oxide biosynthesis by activated macrophages. We have shown that IL-12, a powerful inducer of IFN-<FONT FACE="Symbol">g</font> production by NK cells, is synthesized soon after trypomastigote-macrophage interaction. The role of IL-12 in the control of T. cruzi infection in vivo was determined by treating infected mice with anti-IL-12 monoclonal antibody (mAb) and analyzing both parasitemia and mortality during the... Tipo: Info:eu-repo/semantics/article Palavras-chave: IL-12 Trypanosoma cruzi NK cells IFN-<; FONT FACE=Symbol>; G<; /font>; Nitric oxide. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100014 IFN-g in human Chagas' disease: protection or pathology? BJMBR Bahia-Oliveira,L.M.G.; Gomes,J.A.S.; Rocha,M.O.C.; Moreira,M.C.V.; Lemos,E.M.; Luz,Z.M.P.; Pereira,M.E.S.; Coffman,R.L.; Dias,J.C.P.; Cançado,J.R.; Gazzinelli,G.; Corrêa-Oliveira,R.. An apparently paradoxical role for IFN-<FONT FACE="Symbol">g</font> in human Chagas' disease was observed when studying the pattern of cytokine production by peripheral blood mononuclear cells (PBMC) obtained from two groups of chagasic patients after specific stimulation with Trypanosoma cruzi-derived antigens. The groups studied were 1) patients treated with benznidazole during the acute phase of Trypanosoma cruzi infection and 2) chronically infected untreated patients. In the treated group, higher levels of IFN-<FONT FACE="Symbol">g</font> were produced by PBMC from individuals cured after treatment when compared to non-cured patients. In contrast, in the chronically infected group (not treated) higher levels of IFN-<FONT... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi Chagas' disease cardiomyopathy peripheral blood mononuclear cells (PBMC) cytokines INF-<; FONT FACE=Symbol>; G<; /font>. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100017 Cytokines as determinants of resistance and pathology in human Schistosoma mansoni infection BJMBR Corrêa-Oliveira,R.; Malaquias,L.C.C.; Falcão,P.L.; Viana,I.R.C.; Bahia-Oliveira,L.M.G.; Silveira,A.M.S.; Fraga,L.A.O.; Prata,A.; Coffman,R.L.; Lambertucci,J.R.; Cunha-Melo,J.R.; Martins-Filho,O.A.; Wilson,R.A.; Gazzinelli,G.. The role of different cytokines in the peripheral blood mononuclear cell (PBMC) proliferative response and in in vitro granuloma formation was evaluated in a cross-sectional study with patients with the different clinical forms and phases of Schistosoma mansoni infection, as well as a group of individuals "naturally" resistant to infection named normal endemic (NE). The blockage of IL-4 and IL-5 using anti-IL-4 and anti-IL-5 antibodies significantly reduced the PBMC proliferative response to soluble egg (SEA) and adult worm (SWAP) antigens in acute (ACT), chronic intestinal (INT) and hepatosplenic (HS) patients. Similar results were obtained in the in vitro granuloma formation. Blockage of IL-10 had no significant effect on either assay using PBMC from ACT... Tipo: Info:eu-repo/semantics/article Palavras-chave: Schistosoma mansoni human schistosomiasis mansoni cytokines IL-10 IL-4 IFN-<; FONT FACE=Symbol>; G<; /font>. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100024 Immunologic patterns associated with cure in human American cutaneous leishmaniasis BJMBR Coutinho,S.G.; Da-Cruz,A.M.; Bertho,A.L.; Santiago,M.A.; De-Luca,P.. Patients with American cutaneous leishmaniasis were studied before therapy (active lesion) and at the end of therapy (cured patients). Assays of lymphocyte proliferative responses of peripheral blood mononuclear cells induced in vitro by Leishmania braziliensis promastigote antigens (Lb) were performed. Antigen-stimulated cells were harvested for CD4 and CD8 phenotype analysis and the levels of gamma interferon (IFN-<FONT FACE="Symbol">g</font>) and interleukin 4 (IL-4) produced were also determined in the culture supernatants. Two different patterns of Lb-induced T cell responses were observed: a) predominance of responding CD4+ cells and mixed type 1 and type 2 cytokine production (IFN-<FONT FACE="Symbol">g</font> and IL-4) during... Tipo: Info:eu-repo/semantics/article Palavras-chave: Human cutaneous leishmaniasis Leishmania braziliensis CD4+ and CD8+ cells IFN-<; FONT FACE=Symbol>; G<; /font>; IL-4. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100019 Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules BJMBR Bacellar,O.; Russo,C.; Carvalho,E.M.. It has been shown that HLA class I molecules play a significant role in the regulation of the proliferation of T cells activated by mitogens and antigens. We evaluated the ability of mAb to a framework determinant of HLA class I molecules to regulate T cell proliferation and interferon gamma (IFN-<FONT FACE="Symbol">g</FONT>) production against leishmania, PPD, C. albicans and tetanus toxoid antigens in patients with tegumentary leishmaniasis and healthy subjects. The anti-major histocompatibility complex (MHC) mAb (W6/32) suppressed lymphocyte proliferation by 90% in cultures stimulated with <FONT FACE="Symbol">a</FONT>CD3, but the suppression was variable in cultures stimulated with leishmania antigen. This suppression ranged from... Tipo: Info:eu-repo/semantics/article Palavras-chave: HLA class I tegumentary leishmaniasis modulation of T cell response by HLA class I interferon-<; FONT FACE=Symbol>; G<; /FONT>; And HLA class I soluble antigen and HLA class I. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200010 Registros recuperados: 32 Primeira ... 1 2 ... Última

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