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| MARINHO,KETSIA S.N.; ANTONIO,ERIVALDO A.; SILVA,CAMILLA V.N.S.; SILVA,KEILA T. DA; TEIXEIRA,VALÉRIA W.; AGUIAR JUNIOR,FRANCISCO C.A. DE; SANTOS,KATHARINE R.P. DOS; SILVA,NICÁCIO H. DA; SANTOS,NOEMIA P.S.. |
| ABSTRACT This study aimed to evaluate the teratogenic and hepatotoxic potential of the usnic acid encapsulated into PLGA-microspheres. In total, 12 female Wistar rats in pregnancy were randomly distributed in the control group (n= 6) that received 1.0 mL of physiological solution and treatment group (n= 6) that received 25 mg/kg of encapsulated usnic acid by oral administration. All females were euthanized at day 20 of pregnancy and their fetuses were removed and analyzed. During the pregnancy was observed a reduction in weight gain. There was no difference in serum transaminases levels analyzed as well as any difference in liver weight in both groups. The histomorphometric analysis of the liver from the treatment group revealed an increase in number of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Encapsulation; Fetotoxicity; Hepatotoxicity; Secondary metabolite. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301073 |
