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| Gouvêa,R; Santos,FF dos; Aquino,MHC de; Pereira VL de,A. |
| Fluoroquinolones are antimicrobial agents frequently used in poultry production and in human medicine. The use of such substances must comply with safety criteria, including withdrawal periods, doses, and treatment duration, as their misuse and abuse may cause bacterial resistance and the presence of residues in edible tissues. Consequently, the consumption of animal products with fluoroquinolone residues may result in the transmission of resistant bacteria. In addition, if residues are beyond the acceptable levels, fluoroquinolone active metabolites are harmful to human health. This article presents a review on the use of antimicrobials of the fluoroquinolone class in poultry production, focusing on the development of bacterial resistance to these drugs... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fluoroquinolones; Bacterial resistance; Food residues; Poultry products. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2015000100001 |
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| Baraboutis,Ioannis G; Tsagalou,Eleftheria P; Papakonstantinou,Ilias; Marangos,Markos N; Gogos,Charalambos; Skoutelis,Athanasios T; Bassaris,Haralambos; Johnson,Stuart. |
| OBJECTIVES: Both total antimicrobial use and specific antimicrobials have been implicated as risk factors for healthcare-associated methicillin-resistant Staphylococcus aureus (HCA-MRSA) infection. The aims of this study were: (I) to explore predictors of a new HCA-MRSA infection in comparison with a new healthcare-associated methicillin-sensitive Staphylococcus aureus (HCA-MSSA); (II) to thoroughly assess the role of recent antibiotic use qualitatively and quantitatively. METHODS: The time-period for our study was from October 1997 through September 2001. Through applying strict criteria, we identified two groups of inpatients, one with a new HCA-MRSA infection and one with a new HCA-MSSA infection. We recorded demographic, clinical and antibiotic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Methicillin-resistant Staphylococcus aureus; Staphylococcus aureus; Antibacterial agents; Fluoroquinolones. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500003 |
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| Rocha,Jaime L.; Tuon,Felipe Francisco; Johnson,James R.. |
| BACKGROUND: Optimal empirical therapy of urinary tract infection requires accurate knowledge of local susceptibility patterns, which may vary with organism and patient characteristics. METHODS: Among 9,798 consecutive, non-duplicate, community-source urine isolates from ambulatory patients > 13 years old, from clinical laboratory and an academic medical center in Curitiba, Brazil (May 1st to December 1st, 2009), susceptibility data for ampicillin, nitrofurantoin, trimethoprim-sulfamethoxazole, gentamicin, fluoroquinolones, and ceftriaxone/cefotaxime were compared with organism and patient gender and age. RESULTS: The female-to-male ratio decreased with age, from 28.1 (among 20-29 year-olds) to 3.3 (among > 80 year-olds). Overall, susceptibility... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Urinary tract infections; Anti-bacterial agents; Drug resistance bacterial; Fluoroquinolones; Escherichia coli. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200002 |
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| Chen,Jun; Chen,Zhifei; Li,Yuanyuan; Xia,Wei; Chen,Xi; Chen,Tian; Zhou,Liping; Xu,Bin; Xu,Shunqing. |
| OBJECTIVE: The study aimed to investigate gyrA and gyrB mutations in Mycobacterium tuberculosis (MTB) clinical strains from 93 patients with pulmonary tuberculosis in Hubei Province, China, and analyze the association between mutation patterns of the genes and ofloxacin resistance level. RESULTS: Among 93 MTB clinical isolates, 61 were ofloxacin-resistant by the proportion method, and 32 were ofloxacin-susceptible MDR-TB. No mutation in the gyrB gene was found in any MTB strains. In the 61 ofloxacin-resistant isolates, 54 mutations were observed in the gyrA gene. Only one mutation in the gyrA gene was found in ofloxacin-susceptible MDR-TB isolates. In this study, the mutation patterns of gyrA involved seven patterns of single codon mutation (A90V, S91P,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mycobacterium tuberculosis; Fluoroquinolones; DNA mutational analysis. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200005 |
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| Ahmad,Nafees; Javaid,Arshad; Sulaiman,Syed Azhar Syed; Ming,Long Chiau; Ahmad,Izaz; Khan,Amer Hayat. |
| Abstract Background Fluoroquinolones are the backbone of multidrug resistant tuberculosis treatment regimens. Despite the high burden of multidrug resistant tuberculosis in the country, little is known about drug resistance patterns, prevalence, and predictors of fluoroquinolones resistance among multidrug resistant tuberculosis patients from Pakistan. Objective To evaluate drug resistance patterns, prevalence, and predictors of fluoroquinolones resistance in multidrug resistant tuberculosis patients. Methods This was a cross-sectional study conducted at a programmatic management unit of drug resistant tuberculosis, Lady Reading Hospital Peshawar, Pakistan. Two hundred and forty-three newly diagnosed multidrug resistant tuberculosis patients... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fluoroquinolones; MDR-TB; Resistance; Private. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100041 |
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| Silva,G.C.M.; Jabor,V.A.P.; Bonato,P.S.; Martinez,E.Z.; Faria-e-Sousa,S.J.. |
| We aimed to quantify the penetration of ciprofloxacin, ofloxacin, and moxifloxacin into the cornea and aqueous humor of cadaver eyes. A total of 60 enucleated eyes, not eligible for corneal transplantation, were divided into three groups and immersed in commercial solutions of 0.3% ciprofloxacin, 0.3% ofloxacin, or 0.5% moxifloxacin for 10 min. Whole corneas and samples of aqueous humor were then harvested and frozen, and drug concentrations analyzed by liquid chromatography tandem mass spectrometry. The mean corneal concentration of moxifloxacin was twice as high as ofloxacin, and the latter was twice as high as ciprofloxacin. The mean concentration of moxifloxacin in the aqueous humor was four times higher than the other antibiotics, and the mean... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ciprofloxacin; Eye banking; Eye drops; Fluoroquinolones; Moxifloxacin; Ofloxacin. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000700609 |
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| Yassien,M.A.M.; Elfaky,M.A.. |
| A spontaneous fluoroquinolone-resistant mutant (STM1) was isolated from its parent Salmonella enterica serovar Typhi (S. Typhi) clinical isolate. Unlike its parent isolate, this mutant has selective resistance to fluoroquinolones without any change in its sensitivity to various other antibiotics. DNA gyrase assays revealed that the fluoroquinolone resistance phenotype of the STM1 mutant did not result from alteration of the fluoroquinolone sensitivity of the DNA gyrase isolated from it. To study the mechanism of fluoroquinolone resistance, a genomic library from the STM1 mutant was constructed in Escherichia coli DH5α and two recombinant plasmids were obtained. Only one of these plasmids (STM1-A) conferred the selective fluoroquinolone resistance phenotype... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Salmonella enterica serovar Typhi; Fluoroquinolones; RecA. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001100990 |
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