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	Provedor de dados BJMBR (3) Autor Ajzen,H. (1) Aragão,E.S. (1) Coimbra,T.M. (1) Costa,R.S. (1) Dantas,M. (1) Geleilete,T.J.M. (1) Gerbase-DeLima,M. (1) Martinelli,R. (1) Okumura,A.S. (1) Pereira,L.J. (1) Pereira-Santos,A. (1) Rocha,H. (1) Sesso,R. (1) Silva,O.M.M. (1) Temin,J. (1) Mais... Palavra-chave Focal segmental glomerulosclerosis (3) Alpha-smooth muscle actin (1) Cyclophosphamide (1) Genetics (1) HLA antigens (1) MHC (1) Nephrotic syndrome (1) PCNA (1) Prednisone (1) Primary glomerular disease (1) Proliferating cell nuclear antigen (1) Proteinuria (1) Renal disease progression (1) Renal failure (1) Renal fibrosis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2004 (1) 2001 (1) 1998 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Cyclophosphamide in the treatment of focal segmental glomerulosclerosis BJMBR Martinelli,R.; Pereira,L.J.; Silva,O.M.M.; Okumura,A.S.; Rocha,H.. Prednisone is the initial treatment of primary focal segmental glomerulosclerosis. However, when immunosuppressive agents in combination with steroids are used in the treatment of prednisone-dependent and prednisone-resistant patients the remission rate is variable. We report a long-term trial using cyclophosphamide (2.0 to 3.0 mg/kg body weight for 12 weeks) in combination with prednisone (1.0 to 2.0 mg/kg body weight), as compared with prednisone alone for the treatment of prednisone-resistant and frequently relapsing nephrotic syndrome and focal segmental glomerulosclerosis. Fifty-four patients (34 males and 20 females) with a diagnosis of idiopathic nephrotic syndrome and focal segmental glomerulosclerosis, followed-up for an average of 86.1 ± 82.4... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cyclophosphamide; Prednisone; Nephrotic syndrome; Primary glomerular disease; Focal segmental glomerulosclerosis. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000900011 alpha-Smooth muscle actin and proliferating cell nuclear antigen expression in focal segmental glomerulosclerosis: functional and structural parameters of renal disease progression BJMBR Geleilete,T.J.M.; Costa,R.S.; Dantas,M.; Coimbra,T.M.. The aim of the present study was to investigate the expression of alpha-smooth muscle actin (alpha-SM-actin) and proliferating cell nuclear antigen (PCNA) in renal cortex from patients with focal segmental glomerulosclerosis (FSGS) and their correlations with parameters of renal disease progression. We analyzed renal biopsies from 41 patients with idiopathic FSGS and from 14 control individuals. The alpha-SM-actin immunoreaction was evaluated using a score that reflected the changes in the extent and intensity of staining in the glomerular or cortical area. The PCNA reaction was quantified by counting the labeled cells of the glomeruli or renal cortex. The results, reported as median ± percentile (25th; 75th), showed that the alpha-SM-actin scores in the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Alpha-smooth muscle actin; Proliferating cell nuclear antigen; PCNA; Focal segmental glomerulosclerosis; Proteinuria; Renal failure; Renal disease progression; Renal fibrosis. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000800003 Idiopathic focal segmental glomerulosclerosis and HLA antigens BJMBR Gerbase-DeLima,M.; Pereira-Santos,A.; Sesso,R.; Temin,J.; Aragão,E.S.; Ajzen,H.. The objective of the present study was to investigate a possible association between HLA class II antigens and idiopathic focal segmental glomerulosclerosis (FSGS). HLA-A, -B, -DR and -DQ antigens were determined in 19 Brazilian patients (16 white subjects and three subjects of Japanese origin) with biopsy-proven FSGS. Comparison of the HLA antigen frequencies between white patients and white local controls showed a significant increase in HLA-DR4 frequency among FSGS patients (37.7 vs 17.2%, P<0.05). In addition, the three patients of Japanese extraction, not included in the statistical analysis, also presented HLA-DR4. In conclusion, our data confirm the association of FSGS with HLA-DR4 previously reported by others, thus providing further... Tipo: Info:eu-repo/semantics/article Palavras-chave: Focal segmental glomerulosclerosis; Genetics; HLA antigens; MHC. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000300010 Registros recuperados: 3 Primeira ... 1 ... Última

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