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Enhancing the aqueous solubility and dissolution of olanzapine using freeze-drying BJPS
Dixit,Mudit; Kini,Ashwini Gopalkrishna; Kulkarni,Parthasarthi Keshavarao.
The aim of the present study was to develop an olanzapine freeze-dried tablet (FDT). The solubility and dissolution rate of poorly water-soluble olanzapine was improved by preparing a freeze-dried tablet of olanzapine using the freeze-drying technique . The FDT was prepared by dispersing the drug in an aqueous solution of highly water-soluble carrier materials consisting of gelatin, glycine, and sorbitol. The mixture was poured in to the pockets of blister packs and then was subjected to freezing and lyophilisation. The FDT was characterised by DSC, XRD and SEM and was evaluated for saturation solubility and dissolution. The samples were stored in a stability chamber to investigate their physical stability. Results obtained by DSC and X-ray were analysed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Freeze-dried tablets/development; Olanzapine/freeze-dried tablets; Olanzapine/solubility; Olanzapine/stability; Olanzapine/dissolution; Freeze-drying.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400011
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