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| Didek,Daiane; Cordeiro,Maiara Mikuska; Xavier,João Lucas de Paula; Ribeiro,Paulo Roberto; Rentz,Thiago; Franco,Gilson Cesar Nobre; Kanunfre,Carla Cristine; Emilio,Henriette Rosa de Oliveira; Scomparin,Dionízia Xavier. |
| Abstract The objective of this study was to evaluate the effect of liraglutide, an analog of glucagon-like peptide-1 (GLP-1) in association with physical exercise, on the metabolic and biochemical parameters of rats induced to obesity with a cafeteria diet. Male Wistar rats, aged 21 days, were randomly divided into: Controls (CON) receiving standard feed and water ad libitum; and obese (OBESE) receiving cafeteria diet ad libitum, added to the standard diet. Groups were then subdivided into: Liraglutide animals that received subcutaneous injections of liraglutide from 80 to 90 days of life; exercised (EXE) animals submitted to swimming sessions, three days a week (15 min); and liraglutide + EXE animals that received liraglutide in association with physical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Obesity; Liraglutide; GLP-1; Metabolic syndrome; Exercise. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100305 |
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| Li,Shan; Wang,Xiaoman; Zhang,Jielei; Li,Jingyi; Liu,Xiaogang; Ma,Yuanyuan; Han,Chao; Zhang,Lixia; Zheng,Lili. |
| Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific underlying mechanism is unclear. This study was designed to investigate the underlying molecular mechanisms of exenatide therapy on NAFLD. We used in vivo and in vitro techniques to investigate the protective effects of exenatide on fatty liver via fat mass and obesity associated gene (FTO) in a high-fat (HF) diet-induced NAFLD animal model and related cell culture model. Exenatide significantly... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: GLP-1; FTO; NAFLD; PI3K; Hepatic steatosis. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000800612 |
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