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Association of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension Genet. Mol. Biol.
Nejatizadeh,Azim; Kumar,Rahul; Stobdanand,Tsering; Pasha,Mohammad Qadar.
The role of G-protein activation in cardiovascular disorders is well-known. G-protein β3 subunit (GNB3) C825T polymorphism is associated with increased intracellular signal transduction. We investigated the role of the variant in plasma sodium and potassium concentrations and association with hypertension. 345 healthy controls and 455 patients with essential hypertension were enrolled. Plasma renin activity and aldosterone concentration were measured. The variant, typed by SNaPshot, was analyzed on an ABI Prism 3100 Genetic Analyzer and GeneScan. The TT genotype and T allele were over-represented in the patients (p < 0.001, p < 0.0001). Multiple-logistic regression disclosed that the risk of hypertension was significantly greater for TT (p <...
Tipo: Info:eu-repo/semantics/article Palavras-chave: GNB3 C825T polymorphism; Hypertension; G protein; Plasma electrolytes.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400004
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