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	Provedor de dados BJMBR (1) International Journal of Morphology (1) Autor Chen,Didi (1) Chen,Wei (1) Chen,Xiaolei (1) Dong,Qiantong (1) Hu,Changyuan (1) Manterola,Carlos (1) Otzen,Tamara (1) Sun,Xuecheng (1) Yan,Jingyi (1) Zhou,Feng (1) Mais... Palavra-chave Gastrointestinal stromal tumors (2) GIST (1) GISTs (1) Gastrointestinal stromal tumors/surgery (1) Gastrointestinal stromal tumors/therapy (1) IGF-1R (1) Imatinib resistance (1) Long non-coding RNA CCDC26 (1) Neoadjuvant therapy (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2019 (1) 2016 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Downregulation of lncRNA CCDC26 contributes to imatinib resistance in human gastrointestinal stromal tumors through IGF-1R upregulation BJMBR Yan,Jingyi; Chen,Didi; Chen,Xiaolei; Sun,Xuecheng; Dong,Qiantong; Hu,Changyuan; Zhou,Feng; Chen,Wei. Imatinib is the first line of therapy for patients with metastatic or gastrointestinal stromal tumors (GIST). However, drug resistance limits the long-term effect of imatinib. Long non-coding RNAs (lncRNAs) are emerging as key players in regulating drug resistance in cancer. In this study, we investigated the association between lncRNA CCDC26 and IGF-1R in GIST and their involvement in drug resistance. Considering the key role of lncRNAs in drug resistance in cancer, we hypothesized that IGF-1R is regulated by lncRNAs. The expression of a series of reported drug resistance-related lncRNAs, including CCDC26, ARF, H19, NBR2, NEAT1, and HOTAIR, in GIST cells treated with imatinib H19 was examined at various time-points by qRT-PCR. Based on our results and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Long non-coding RNA CCDC26; Gastrointestinal stromal tumors; GIST; IGF-1R; Imatinib resistance. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000600610 Gastrointestinal Stromal Tumors (GISTs): Single Center Experience Observed in a Small Series of Cases International Journal of Morphology Manterola,Carlos; Otzen,Tamara. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms developing in the stomach. Usually detected incidentally, they can be single or multiple. The aim of this study is to report the results of surgery in the treatment of GISTs in terms of postoperative morbidity (POM) and recurrence. Case series. Patients surgically treated by GISTs at the Clínica Mayor of Temuco, Chile, between 2008 and 2015 were included. The preoperative study consisted in general diagnostic tests, endoscopy and abdominal CT-Scan. The outcome variable was POM, measured at 30 days postoperatively. Other variables of interest were: surgical time, hospital stay, mortality and recurrence. Minimum follow-up time was 12 months. Descriptive statistics were used.... Tipo: Journal article Palavras-chave: Gastrointestinal stromal tumors; Gastrointestinal stromal tumors/surgery; Gastrointestinal stromal tumors/therapy; Neoadjuvant therapy; GISTs. Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200011 Registros recuperados: 2 Primeira ... 1 ... Última

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