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| Chae,Song Wha; Jee,Bo Keun; Lee,Joo Yong; Han,Chang Whan; Jeon,Yang-Whan; Lim,Young; Lee,Kweon-Haeng; Rha,Hyoung Kyun; Chae,Gue-Tae. |
| Human bone marrow-derived mesenchymal stem cells (hMSCs) have the capacity to differentiate into osteoblasts during osteogenesis. Several studies attempted to identify osteogenesis-related genes in hMSCs. Although HOX genes are known to play a pivotal role in skeletogenesis, their function in the osteogenesis of hMSCs has not yet been investigated in detail. Our aim was to characterize the expression of 37 HOX genes by multiplex RT-PCR to identify the ones most probably involved in osteogenic differentiation. The results showed that the expression patterns of four HOX genes were altered during this process. In particular, the expression levels of HOXC13 and HOXD13 were dramatically changed. Real-time PCR and Western blot analysis were performed... |
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Palavras-chave: Human mesenchymal stem cells; HOX genes; Osteogenic differentiation; Stem cell differentiation; Gene profiling. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000500002 |
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| Li,X; Su,S; Cui,N; Zhou,H; Liu,X; Cui,Z. |
| ABSTRACT Marek’s disease (MD), a lymphoproliferative disorder of chickens caused by the MD virus (MDV), is economically significant. The resistance/susceptibility to MD is controlled by host genetics. The host response to different virus strains varies. The pathogenicity of REV-LTR deleted GX0101∆LTR MDV has been previously reported. However, the precise molecular mechanism of the response of chickens to GX0101ΔLTR remains unclear. The current study aimed at identifying the genes and pathways involved in the response to GX0101ΔLTR virus infection in specific pathogen-free chicken embryo fibroblast cells using global transcriptome analysis. A total of 1,633 genes associated with GX0101ΔLTR infection were identified. Functional analysis showed that the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gene profiling; Chicken; CEF cell; GX0101ΔLTR MDV.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2017000200179 |
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