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	Provedor de dados BJMBR (1) BJM (1) Autor Granato,Celso Francisco Hernandes (1) Mendes,L.C. (1) Miotto,N. (1) Passos-Castilho,Ana Maria (1) Stucchi,R.S.B. (1) Vigani,A.G. (1) Zanaga,L.P. (1) Mais... Palavra-chave Genotype 3 (2) Brazil (1) Daclatasvir (1) Hepatitis C treatment (1) Hepatitis E virus (1) Pigs (1) Ribavirin (1) Sofosbuvir (1) Zoonosis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2016 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Treatment of hepatitis C virus genotype 3 infection with direct-acting antiviral agents BJMBR Zanaga,L.P.; Miotto,N.; Mendes,L.C.; Stucchi,R.S.B.; Vigani,A.G.. Hepatitis C virus (HCV) genotype 3 is responsible for 30.1% of chronic hepatitis C infection cases worldwide. In the era of direct-acting antivirals, these patients have become one of the most challenging to treat, due to fewer effective drug options, higher risk of developing cirrhosis and hepatocellular carcinoma and lower sustained virological response (SVR) rates. Currently there are 4 recommended drugs for the treatment of HCV genotype 3: pegylated interferon (PegIFN), sofosbuvir (SOF), daclatasvir (DCV) and ribavirin (RBV). Treatment with PegIFN, SOF and RBV for 12 weeks has an overall SVR rate of 83–100%, without significant differences among cirrhotic and non-cirrhotic patients. However, this therapeutic regimen has several contraindications and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C treatment; Genotype 3; Sofosbuvir; Daclatasvir; Ribavirin. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001100302 High frequency of hepatitis E virus infection in swine from South Brazil and close similarity to human HEV isolates BJM Passos-Castilho,Ana Maria; Granato,Celso Francisco Hernandes. Abstract Hepatitis E virus is responsible for acute and chronic liver infections worldwide. Swine hepatitis E virus has been isolated in Brazil, and a probable zoonotic transmission has been described, although data are still scarce. The aim of this study was to investigate the frequency of hepatitis E virus infection in pigs from a small-scale farm in the rural area of Paraná State, South Brazil. Fecal samples were collected from 170 pigs and screened for hepatitis E virus RNA using a duplex real-time RT-PCR targeting a highly conserved 70 nt long sequence within overlapping parts of ORF2 and ORF3 as well as a 113 nt sequence of ORF2. Positive samples with high viral loads were subjected to direct sequencing and phylogenetic analysis. hepatitis E virus... Tipo: Info:eu-repo/semantics/article Palavras-chave: Brazil; Genotype 3; Hepatitis E virus; Pigs; Zoonosis. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000200373 Registros recuperados: 2 Primeira ... 1 ... Última

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