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Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids Genet. Mol. Biol.
Guimarães,Larissa O.; Andrade,Fabiana A. de; Bono,Gleyse F.; Setoguchi,Thaís E.; Brandão,Mariana B.; Chautard-Freire-Maia,Eleidi A.; Santos,Izabella C.R. dos; Picheth,Geraldo; Faria,Ana Cristina R. de A.; Réa,Rosângela R.; Souza,Ricardo L.R.; Furtado-Alle,Lupe.
Many conditions interfere with butyrylcholinesterase (BChE) activity, e.g., pregnancy or presence of the BCHE gene variant -116A can decrease activity whereas obesity and types I and II diabetes mellitus can increase activity. In this study, we examined BChE activity, -116A and 1615A BCHE gene variants, and anthropometric and biochemical variables associated with diabetes in patients with gestational diabetes mellitus (GDM) and in healthy pregnant women. BChE activity was measured spectrophotometrically using propionylthiocholine as substrate and genotyping of the -116 and 1615 sites of the BCHE gene was done with a TaqMan SNP genotyping assay. Three groups were studied: 150 patients with GDM, 295 healthy pregnant women and 156 non-pregnant healthy women....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Butyrylcholinesterase (BChE); Gestational diabetes mellitus; -116A variant; 1615A variant.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000100003
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Expression of PECAM-1 and E-Cadherin in the Umblical Cords of Gestational Diabetic Mothers International Journal of Morphology
Tahaoglu,A. E; Togrul,C; Külahcioglu,M. I; Bademkiran,M. H; Balsak,D; Mavi gök,E; Ekinci,C; Deveci,E.
The purpose of this study is to examine the changes in the umbilical cord in women diagnosed with gestational diabetes mellitus In this study, as a control group human placental tissues from normotensive pregnancies was collected from diabetic women at 28­35 weeks of gestation. Gestational diabetes (n= 20) and normal umbilical cord (n= 20) for a total of 40 units were received.GDM groups compared to the control group was significantly higher values was detected (p<0.01). In GDM group, light microscopy showed erosion of the endothelium and complete rupture of theumbilicalvessels resulting in extravasation of blood within Wharton's jelly. it was observed that the cytoplasmic fragments and cell infiltration of the spill to the subepithelial layer of...
Tipo: Journal article Palavras-chave: Gestational diabetes mellitus; PECAM-1; Umblical cord; E-Cadherin.
Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000400014
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Gestational Diabetes Induces Pancreatic Beta-Cells Apoptosis in Adult Rat Offspring International Journal of Morphology
Nazari,Zahra; Nabiuni,Mohammad; Ghaffari,Soraya; Saeidi,Mohsen; Shahriyari,Alireza; Golalipour,Mohammad Jafar.
Several studies indicated that pancreatic ß-cell death occurs in both type 1 and type 2 diabetes. This experimental study was designed to determine the effect of gestational diabetes on the ß-cells in 16-week-old rat offspring. By this aim, adult Wistar rats aged 10-12 weeks were randomly allocated in control and diabetic groups. The diabetic group received 40 mg/kg/body weight of streptozotocin (STZ) on day zero of gestation. After delivery, diabetic offspring of GDM mothers and controls at the age of 16 weeks were sacrificed and pancreases harvested and fixed. The number of ß-cells and were counted by Gomori's method staining. Also, apoptosis in pancreas tissue of diabetic and control offspring was detected by TUNEL assay. Results showed a significant...
Tipo: Journal article Palavras-chave: Gestational diabetes mellitus; Pancreatic islets (Langerhans); SS-cell; Apoptosis; Rat offspring.
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100003
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The Effect of Gestational Diabetes Mellitus on Sciatic Nerve in Adult Offspring Rats International Journal of Morphology
Ameri,Mehdi; Ghafari,Soraya; Nazari,Zahra; Mehdizadeh,Mehdi; Shekari,Majid Asadi; Golalipour,Mohammadjafar.
Gestational diabetes mellitus (GDM) is one form of diabetes affect approximately 7 % of pregnancies. Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that is associated with loss of nerve fibers, myelin abnormalities and significant decrease in the expression of myelin basic protein (MBP) in peripheral nerves. This study was done to determine the effect of induced diabetes during pregnancy on sciatic nerve in adult rat offspring. In this study, wistar rats' dams were allocated to control and diabetic groups. Diabetic rats were received 40 mg/kg/body weight of streptozotocin (STZ) on the first day of gestation. Six offspring of each group were randomly selected on 12 weeks postnatal and histopathological changes in their nerve...
Tipo: Journal article Palavras-chave: Gestational diabetes mellitus; Sciatic nerve; Myelin basic protein; Schwannocytus (Schwann cell).
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100026
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Ultrastructural Changes in the Placental Membrane in Pregnancies Associated with Diabetes International Journal of Morphology
Verma,Ranjana; Mishra,S; Kaul,Jagat Mohini.
Placenta is the most accurate record of the infant prenatal experience. If the placenta is examined minutely after delivery, it provides much insight into the prenatal health of the baby and the mother. The weight of placenta is higher in diabetic pregnancy in comparison to the normal pregnancy. To study the cellular changes that might contribute to more weight of placenta in diabetic pregnancies, light microscopic and electron microscopic analysis was performed. Twenty singleton pregnancies complicated with Gestational diabetes mellitus (12 controlled on diet, 8 controlled on insulin) were selected and compared to control group. Tissue sections were processed and analyzed. The placenta of diabetic pregnancies showed no abnormality on gross observation but...
Tipo: Journal article Palavras-chave: Gestational diabetes mellitus; Transmission electron Microscopy; Placental membrane.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400056
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