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| Sacher,Johannes; Saa,Pedro; Cárcamo,Martín; López,Javiera; Gelmi,Claudio A; Pérez-Correa,Ricardo. |
| Background: Calibration of dynamic models in biotechnology is challenging. Kinetic models are usually complex and differential equations are highly coupled involving a large number of parameters. In addition, available measurements are scarce and infrequent, and some key variables are often non-measurable. Therefore, effective optimization and statistical analysis methods are crucial to achieve meaningful results. In this research, we apply a metaheuristic scatter search algorithm to calibrate a solid substrate cultivation model. Results: Even though scatter search has shown to be effective for calibrating difficult nonlinear models, we show here that a posteriori analysis can significantly improve the accuracy and reliability of the estimation.... |
| Tipo: Journal article |
Palavras-chave: Gibberella fujikuroi; Gibberellic acid; Global optimization; Metaheuristics; Nonlinear dynamic models; Parameter estimation; Solid substrate cultivation. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582011000500007 |
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| Carvajal,Marcela; Espinoza,Luis; Caggia,Silvia; Cardile,Venera; Garbarino,Juan A; Peña-Cortés,Hugo; Russo,Alessandra. |
| Background: Several studies have shown that (-)-Jasmonic acid, (+)-7-iso-Jasmonic acid and its methyl ester, methyl jasmonate, have anti-cancer activity in vitro and in vivo, exhibiting selective cytotoxicity towards cancer cells. The degree of activity of these molecules is strongly related to their stereochemistry. The biotransformation of known compounds, natural or synthesized, related to interesting biological activities, generates new molecules displaying new improved properties compared with the original ones, increasing its value and providing new more effective products. Therefore, based on the above rationales and observations, in this work a biotransformation protocol to modify the chemical structure of the plant hormone jasmonic acid by using... |
| Tipo: Journal article |
Palavras-chave: Apoptosis; Biotransformations; Cancer cells; Cell vitality; Gibberella fujikuroi; Jasmonic acid. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582011000200007 |
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