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| MIRANDA,CAROLINA A.; SCHÖNHOLZER,TATIELE E.; KLÖPPEL,EDUARDO; SINZATO,YURI K.; VOLPATO,GUSTAVO T.; DAMASCENO,DÉBORA C.; CAMPOS,KLEBER E.. |
| Abstract Fructose consumption has increased worldwide, and it has been associated with the development of metabolic diseases such as insulin resistance (IR) and steatosis. The aim was to evaluate if lower fructose concentrations may cause pancreatic structural abnormalities, leading to a glucose intolerance without steatosis in male rats. Young male rats orally received 7% fructose solution for 12 weeks. Body weight, food, water, and energy intake were measured. An oral glucose tolerance test (OGTT) was performed. After final experimental period, all rats were anaesthetized and killed. Blood samples were collected for biochemical analyses and organs (liver and pancreas) were processed for morphological analyses. Fructose consumption was not associated with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fructose; Glucose intolerance; Islet pancreatic; Steatosis. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100702 |
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| Franco,L.F.; Crispim,F.; Pereira,A.C.; Moisés,R.S.. |
| Common variants of the transcription factor 7-like 2 (TCF7L2) gene have been found to be associated with type 2 diabetes in different ethnic groups. The Japanese-Brazilian population has one of the highest prevalence rates of diabetes. Therefore, the aim of the present study was to assess whether two single-nucleotide polymorphisms (SNPs) of TCF7L2, rs7903146 and rs12255372, could predict the development of glucose intolerance in Japanese-Brazilians. In a population-based 7-year prospective study, we genotyped 222 individuals (72 males and 150 females, aged 56.2 ± 10.5 years) with normal glucose tolerance at baseline. In the study population, we found that the minor allele frequency was 0.05 for SNP rs7903146 and 0.03 for SNP rs12255372. No significant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: TCF7L2; Glucose intolerance; Japanese-Brazilians. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000300011 |
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| Molena-Fernandes,C.; Bersani-Amado,C. A.; Ferraro,Z. M.; Hintze,L. J.; Nardo Jr.,N.; Cuman,R. K. N.. |
| We aimed to evaluate the effects of aerobic exercise training (4 days) and metformin exposure on acute glucose intolerance after dexamethasone treatment in rats. Forty-two adult male Wistar rats (8 weeks old) were divided randomly into four groups: sedentary control (SCT), sedentary dexamethasone-treated (SDX), training dexamethasone-treated (DPE), and dexamethasone and metformin treated group (DMT). Glucose tolerance tests and in situ liver perfusion were undertaken on fasting rats to obtain glucose profiles. The DPE group displayed a significant decrease in glucose values compared with the SDX group. Average glucose levels in the DPE group did not differ from those of the DMT group, so we suggest that exercise training corrects dexamethasone-induced... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Exercise; Glucose intolerance; Dexamethasone; Wistar rats; Diabetes mellitus; Prevention and control. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001201101 |
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