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	Provedor de dados Biol. Res. (1) Autor AGUIRRE,PABLA (1) ARACENA,PAULA (1) MUÑOZ,PABLO (1) NÚÑEZ,MARCO T (1) Palavra-chave Glutathione metabolism (1) Iron accumulation (1) Iron metabolism (1) Neurodegeneration (1) Neurons (1) Oxidative stress (1) Mais... Tipo do documento Journal article (1) Ano 2006 (1) País Chile (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Iron and glutathione at the crossroad of redox metabolism in neurons Biol. Res. ARACENA,PAULA; AGUIRRE,PABLA; MUÑOZ,PABLO; NÚÑEZ,MARCO T. Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic... Tipo: Journal article Palavras-chave: Neurons; Iron metabolism; Iron accumulation; Oxidative stress; Glutathione metabolism; Neurodegeneration. Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100017 Registros recuperados: 1 Primeira ... 1 ... Última

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