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Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2) BJMBR
Poli-Neto,A.; Nonoyama,K.; Oshiro,M.; Ebner-Filho,W.; Miguita,K.; Medeiros,T.M.D.; Watanabe,C.I.; Barretto,O.C.O..
Fetal hemoglobin was measured in HIV1/2 patients under treatment with combined therapy (zidovudine and a protease inhibitor). A total of 143 patients and 103 normal individuals were investigated by the quantitative method of Betke and the semi-quantitative acid elution method of Kleihauer. In the normal person, hemoglobin F makes up less than 1% and an increase higher than 1.5% was observed in 21.4% of HIV patients by the method of Betke and in 24.8% of HIV-infected patients by the method of Kleihauer. The quantitative biochemical method of Betke showed that the populations were significantly different (two-tailed Mann-Whitney test). The reason for this hemoglobin F increase might be ascribed to the effect of zidovudine or to direct viral action on gamma...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Human immunodeficiency virus; HIV1/2; Hemoglobin; Fetal hemoglobin; F cells; Zidovudine.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100008
Registros recuperados: 1
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