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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor Askun,Tülin (1) Aydeniz,Hatice (1) Bhushan,Shashi (1) Chen,C. (1) Gao,L. (1) Ngogang,Jeanne Yonkeu (1) Pieme,Constant Anatole (1) Santosh,Guru Kumar (1) Saxena,Ajit Kumar (1) Sun,Y. (1) Tekwu,Emmanuel Mouafo (1) Wang,J. (1) Wang,Z. (1) Xi,Y. (1) Mais... Palavra-chave Apoptosis (2) HL-60 cells (2) Agaricus blazei Murill (1) Caspase-3 (1) Fraction FA-2-b-ß (1) Mitochondrial membrane potential (1) ROS (1) Syringic acid (1) Telomerase (1) Zanthozyllum heitzii (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2014 (1) 2007 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells Biol. Res. Pieme,Constant Anatole; Santosh,Guru Kumar; Tekwu,Emmanuel Mouafo; Askun,Tülin; Aydeniz,Hatice; Ngogang,Jeanne Yonkeu; Bhushan,Shashi; Saxena,Ajit Kumar. BACKGROUND: Zanthoxylum heitzii is a spice used to prepare several dishes and to treat tumors, syphilis, malaria, cardiac palpitations, urogenital infections in the west region of Cameroon, but the antitumor mechanisms and chemical composition are not yet investigated. This study was aimed to determine the antiproliferative effects of four extracts from the fruits and barks of Zanthoxyllum heitzii (Rutaceae) on apoptosis in human promyelocytic cells, their mechanisms and the chemical composition. The 3-(4, 5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the fifty percent inhibition (IC50) concentration of the cell lines after treatment. The effect on morphology was observed using a light or fluorescence... Tipo: Journal article Palavras-chave: Zanthozyllum heitzii; Syringic acid; Apoptosis; HL-60 cells; ROS; Mitochondrial membrane potential. Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100048 Primary mechanism of apoptosis induction in a leukemia cell line by fraction FA-2-b-ß prepared from the mushroom Agaricus blazei Murill BJMBR Gao,L.; Sun,Y.; Chen,C.; Xi,Y.; Wang,J.; Wang,Z.. Agaricus blazei Murill is a native Brazilian mushroom which functions primarily as an anticancer substance in transplanted mouse tumors. However, the mechanism underlying this function of A. blazei Murill remains obscure. The present study was carried out to investigate the effect of fraction FA-2-b-ß, an RNA-protein complex isolated from A. blazei Murill, on human leukemia HL-60 cells in vitro. Typical apoptotic characteristics were determined by morphological methods using DNA agarose gel electrophoresis and flow cytometry. The growth suppressive effect of fraction FA-2-b-ß on HL-60 cells in vitro occurred in a dose- (5-80 µg/mL) and time-dependent (24-96 h) manner. The proliferation of HL-60 cells (1 x 10(5) cells/mL) treated with 40 µg/mL of fraction... Tipo: Info:eu-repo/semantics/article Palavras-chave: Agaricus blazei Murill; Fraction FA-2-b-ß; Apoptosis; Caspase-3; Telomerase; HL-60 cells. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100015 Registros recuperados: 2 Primeira ... 1 ... Última

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