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| Geiger, Marie; Desanglois, Gwenaelle; Hogeveen, Kevin; Fessard, Valerie; Lepretre, Thomas; Mondeguer, Florence; Guitton, Yann; Herve, Fabienne; Sechet, Veronique; Grovel, Olivier; Pouchus, Yves-francois; Hess, Philipp. |
| Pinnatoxin G (PnTX-G) is a marine toxin belonging to the class of cyclic imines and produced by the dinoflagellate Vulcanodinium rugosum. In spite of its strong toxicity to mice, leading to the classification of pinnatoxins into the class of “fast-acting toxins”, its hazard for human health has never been demonstrated. In this study, crude extracts of V. rugosum exhibited significant cytotoxicity against Neuro2A and KB cells. IC50 values of 0.38 µg mL−1 and 0.19 µg mL−1 were estimated on Neuro2A cells after only 24 h of incubation and on KB cells after 72 h of incubation, respectively. In the case of Caco-2 cells 48 h after exposure, the crude extract of V. rugosum induced cell cycle arrest accompanied by a dramatic increase in double strand DNA breaks,... |
| Tipo: Text |
Palavras-chave: Dereplication; Cyclic imine; HRMS; Bioactivity; Pinnatoxins. |
| Ano: 2013 |
URL: http://archimer.ifremer.fr/doc/00156/26723/24802.pdf |
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| Estevez, Pablo; Sibat, Manoella; Leão-martins, José Manuel; Tudó, Angels; Rambla-alegre, Maria; Aligizaki, Katerina; Diogène, Jorge; Gago-martinez, Ana; Hess, Philipp. |
| Over the last decade, knowledge has significantly increased on the taxonomic identity and distribution of dinoflagellates of the genera Gambierdiscus and Fukuyoa. Additionally, a number of hitherto unknown bioactive metabolites have been described, while the role of these compounds in ciguatera poisoning (CP) remains to be clarified. Ciguatoxins and maitotoxins are very toxic compounds produced by these dinoflagellates and have been described since the 1980s. Ciguatoxins are generally described as the main contributors to this food intoxication. Recent reports of CP in temperate waters of the Canary Islands (Spain) and the Madeira archipelago (Portugal) triggered the need for isolation and cultivation of dinoflagellates from these areas, and their... |
| Tipo: Text |
Palavras-chave: Maitotoxins; Ciguatoxins; Gambierdiscus; Fukuyoa; LC-MS; MS; HRMS; QToF; Ciguatera poisoning. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00629/74081/73530.pdf |
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