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Construction of adenoviral vectors expressing F and G glycoproteins of human respiratory syncytial virus (HRSV) BJM
Kosaka,Ithana Monteiro; Carromeu,Cassiano; Durigon,Edison Luiz; Ventura,Armando Morais.
Human Respiratory Syncytial Virus (HRSV) was first characterized in 1957 and has since been recognized as the most common viral cause of severe respiratory tract infection in young infants worldwide. Despite many years of research there is still no effective treatment or any immediate prospect of a vaccine. The HRSV genome is composed of single stranded negative sense RNA and the virion consists of a nucleocapsid packaged within a lipid envelope. The envelope contains spike-like projections, each being a homo-oligomer of one of three transmembrane viral envelope proteins: the attachment protein G, the fusion protein F involved in viral penetration and the small hydrofobic protein SH. The aim of this work was to construct two recombinant...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Respiratory Syncytial Virus; Adenoviral vectors; Protein Expression; HRSV F protein; HRSV G protein.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000100028
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