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| Turek,Luciane Viater; Leite,Neiva; Souza,Ricardo Lehtonen Rodrigues; Lima,Jovana Karoline; Milano,Gerusa Eisfeld; Timossi,Luciana da Silva; Osiecki,Ana Claudia Vecchi; Osiecki,Raul; Alle,Lupe Furtado. |
| In this study, we investigated the influence of two SNPs (rs846910 and rs12086634) of the HSD11B1 gene that encodes 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1), the enzyme that catalyzes the conversion of cortisol to cortisone, on variables associated with obesity and metabolic syndrome in 215 individuals of both sexes from southern Brazil. The HSD11B1 gene variants were genotyped using the TaqMan SNP genotyping assay. Glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol were measured by standard automated methods. Significant results were found in women, with carriers of the G allele of SNP rs12086634 having higher glucose levels than non-carriers. Carriers of the A allele of SNP rs846910 had higher levels of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HSD11B1 gene; Men; Metabolism; Metabolic syndrome; Women. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000400003 |
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